Absorption of Flavonols Derived from Sea Buckthorn (Hippophaë rhamnoides L.) and Their Effect on Emerging Risk Factors for Cardiovascular Disease in Humans

Sea buckthorn (Hippophaë rhamnoides L.) is a rich source of flavonols, especially isorhamnetin. Most prospective cohort studies have indicated some degree of inverse association between flavonoid intake and coronary heart disease. Animal and human studies suggest that sea buckthorn flavonoids may sc...

Full description

Saved in:
Bibliographic Details
Published in:Journal of agricultural and food chemistry 2006-09, Vol.54 (19), p.7364-7369
Main Authors: Suomela, Jukka-Pekka, Ahotupa, Markku, Yang, Baoru, Vasankari, Tommi, Kallio, Heikki
Format: Article
Language:English
Subjects:
Adult
antioxidant activity
antioxidants
Antioxidants - analysis
Aryldialkylphosphatase - blood
Avena
bioavailability
Biological and medical sciences
blood viscosity
C-Reactive Protein - analysis
cardiac output
cardiovascular diseases
Cardiovascular Diseases - prevention & control
Chromatography, High Pressure Liquid
Diet
disease prevention
dosage
Double-Blind Method
enzyme activity
essential oils
esterases
flavonols
Flavonols - administration & dosage
Flavonols - pharmacokinetics
Flavonols - therapeutic use
Food industries
free radicals
Fundamental and applied biological sciences. Psychology
herbal medicines
Hippophae - chemistry
Hippophae rhamnoides
Homocysteine - blood
Humans
Intestinal Absorption
Lipoproteins, LDL - blood
Male
medicinal properties
Middle Aged
paraoxonase
Placebos
Plant Oils - administration & dosage
Plant Oils - chemistry
Quercetin - analogs & derivatives
risk factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sea buckthorn (Hippophaë rhamnoides L.) is a rich source of flavonols, especially isorhamnetin. Most prospective cohort studies have indicated some degree of inverse association between flavonoid intake and coronary heart disease. Animal and human studies suggest that sea buckthorn flavonoids may scavenge free radicals, lower blood viscosity, and enhance cardiac function. The effects of flavonol aglycones derived from sea buckthorn on the risk factors of cardiovascular disease as well as their absorption were studied in humans. The flavonols, ingested with oatmeal porridge, did not have a significant effect on the levels of oxidized low-density lipoprotein, C-reactive protein, and homocysteine, on the plasma antioxidant potential, or on the paraoxonase activity. Flavonols at two dosages in oatmeal porridge were rapidly absorbed, and a relatively small amount of sea buckthorn oil added to the porridge seemed to have increased the bioavailability of sea buckthorn flavonols consumed at the higher dose. Keywords: Flavonols; flavonol absorption; oxidized LDL; lipid oxidation; high-performance liquid chromatography; baseline diene conjugation; cardiovascular disease
ISSN:0021-8561
1520-5118
DOI:10.1021/jf061889r