The first synthesis of chiral PNA monomer-cyclen conjugates

A synthetic route to novel chiral PNA monomer‐cyclen conjugates was described for the first time, the targeted products were obtained in high yields under mild reaction conditions. The preliminary results demonstrated that the uracil‐PNA monomer‐cyclen conjugates can rapidly bind Zn2+ in aqueous sol...

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Bibliographic Details
Published in:Journal of peptide science 2005-12, Vol.11 (12), p.812-817
Main Authors: Ma, Li-Jian, Zhang, Guo-Lin, Chen, Shan-Yong, Wu, Bo, You, Jing-Song, Xia, Chuan-Qin, Yu, Xiao-Qi
Format: Article
Language:English
Subjects:
1,4,7,10‐tetraazacyclododecane (cyclen)
10-tetraazacyclododecane (cyclen)
Circular Dichroism
conjugates
Heterocyclic Compounds - chemistry
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
peptide nucleic acids (PNA)
Peptide Nucleic Acids - chemical synthesis
Peptide Nucleic Acids - chemistry
Stereoisomerism
synthesis
Uracil - chemistry
Zinc - chemistry
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Summary:A synthetic route to novel chiral PNA monomer‐cyclen conjugates was described for the first time, the targeted products were obtained in high yields under mild reaction conditions. The preliminary results demonstrated that the uracil‐PNA monomer‐cyclen conjugates can rapidly bind Zn2+ in aqueous solution, and the structure of the Zn(II) complex was confirmed facilely by HRMS spectra, 1H NMR spectra and elemental analysis. Copyright © 2005 European Peptide Society and John Wiley & Sons, Ltd.
ISSN:1075-2617
1099-1387
DOI:10.1002/psc.685