A Case of Classical Polyarteritis Nodosa Complicated by Ulcerative Colitis

Classical polyarteritis nodosa (PAN) is a term that includes patients with necrotizing inflammation of medium-sized arteries and excludes those with microscopic vessel involvement. Although gastrointestinal manifestations are not unusual in patients with classical PAN, the association with ulcerativ...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of the medical sciences 2006-09, Vol.332 (3), p.137-139
Main Authors: Okamoto, Kenta, Shikuwa, Saburo, Ikeda, Yukiko, Migita, Kiyoshi, Ishibashi, Hiromi, Ito, Masahiro, Miyazato, Masaru, Eguchi, Katsumi
Format: Article
Language:English
Subjects:
ANCA
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biological and medical sciences
Colitis, Ulcerative - complications
Colitis, Ulcerative - drug therapy
General aspects
Humans
Immunosuppressive Agents - therapeutic use
Male
Medical sciences
Middle Aged
Polyarteritis nodosa
Polyarteritis Nodosa - complications
Polyarteritis Nodosa - drug therapy
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Ulcerative colitis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Classical polyarteritis nodosa (PAN) is a term that includes patients with necrotizing inflammation of medium-sized arteries and excludes those with microscopic vessel involvement. Although gastrointestinal manifestations are not unusual in patients with classical PAN, the association with ulcerative colitis has been reported only rarely. We describe a patient with classical PAN complicated by bilateral renal artery aneurysms with subsequent rapture and perirenal hemorrhages. He was successfully treated, and the bilateral renal aneurysms resolved with steroid therapy. Two years later, the patient presented with hematochezia. Colonoscopy revealed inflamed rectal mucosa with bleeding ulcers. Histologic findings of biopsy specimens showed severe mucosal inflammation and crypt abscess. The patient was diagnosed with ulcerative colitis, and the symptoms attenuated after meselazine therapy.
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-200609000-00008