Plasma Cell Dyscrasia with Kappa Light-chain Crystals in Proximal Tubular Cells: A Histological, Immunofluorescent, and Ultrastructural Study

This is a case report of a 56-year-old man with plasma cell dyscrasia who presented with proximal tubulopathy manifested as kappa light-chain crystal deposition in the proximal convoluted tubular cells. This was associated with mild cellular damage. The crystals were seen as negative images with the...

Full description

Saved in:
Bibliographic Details
Published in:Ultrastructural pathology 2006-07, Vol.30 (4), p.315-319
Main Authors: Cai, Guoping, Sidhu, Gurdip S., Wieczorek, Rosemary, Gu, Xin, Herrera, Guillermo A., Cubukcu-Dimopulo, Olcay, Kahn, Thomas
Format: Article
Language:English
Subjects:
crystal
Crystallization
Fluorescent Antibody Technique
Humans
immunoelectron microscopy
Immunoglobulin kappa-Chains - chemistry
Immunoglobulin kappa-Chains - metabolism
kappa light-chain
Kidney Tubules, Proximal - metabolism
Kidney Tubules, Proximal - pathology
Male
Microscopy, Electron
Microscopy, Immunoelectron
Middle Aged
Paraproteinemias - metabolism
Paraproteinemias - pathology
plasma cell dyscrasia
proximal tubulopathy
ultrastructure
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This is a case report of a 56-year-old man with plasma cell dyscrasia who presented with proximal tubulopathy manifested as kappa light-chain crystal deposition in the proximal convoluted tubular cells. This was associated with mild cellular damage. The crystals were seen as negative images with the hematoxylin-eosin and periodic acid-Schiff (PAS) stains. They were identified as kappa light-chains by immunofluorescent imaging and confirmed by immunoelectron microscopy. Ultrastructurally, the crystals appear to be located within lysosomes. No deposits of light-chains were seen elsewhere in the kidney biopsy.
ISSN:0191-3123
1521-0758
DOI:10.1080/019131290945727