Chronological distribution of Rip immunoreactivity in the gerbil hippocampus during normal aging

Age-dependent studies on oligodendrocytes, which are the myelinating cells in the central nervous system, have been relatively less investigated. We examined age-dependent changes in Rip immunoreactivity and its protein level in the gerbil hippocampus during normal aging using immunohistochemistry a...

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Bibliographic Details
Published in:Neurochemical research 2006-09, Vol.31 (9), p.1119-1125
Main Authors: Hwang, In Koo, Yoo, Ki-Yeon, Kim, Dong Shoo, Kang, Tae-Cheon, Lee, Bong-Hee, Kim, Yong-Sun, Won, Moo Ho
Format: Article
Language:English
Subjects:
Age
Aging
Aging - physiology
Animals
Antibodies
Antibodies, Monoclonal
Biomarkers - metabolism
Central nervous system
Dentate gyrus
Gerbillinae
Hippocampus
Hippocampus - cytology
Hippocampus - metabolism
Immunohistochemistry
Male
Nerve Tissue Proteins - metabolism
Oligodendrocytes
Oligodendroglia - cytology
Oligodendroglia - metabolism
Proteins
Stratum radiatum
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Summary:Age-dependent studies on oligodendrocytes, which are the myelinating cells in the central nervous system, have been relatively less investigated. We examined age-dependent changes in Rip immunoreactivity and its protein level in the gerbil hippocampus during normal aging using immunohistochemistry and Western blot analysis with Rip antibody, an oligodendrocyte marker. Rip immunoreactivity and its protein level in the hippocampal CA1 region significantly increased at postnatal month 3 (PM 3). Thereafter, they decreased in the hippocampal CA1 region with age. At PM 24, Rip immunoreactive processes in the hippocampal CA1 region markedly decreased in the stratum radiatum. In the hippocampal CA2/3 region and dentate gyrus, the pattern of changes in Rip immunoreactivity and its protein level was similar to those in the hippocampal CA1 region; however, no significant changes were found in the CA2/3 region and dentate gyrus at various age stages. These results indicate that Rip immunoreactivity and protein level in the hippocampal CA1 region decreases significantly at PM 24 compared to the CA2/3 region and dentate gyrus.
ISSN:0364-3190
1573-6903
DOI:10.1007/s11064-006-9129-4