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Chronological distribution of Rip immunoreactivity in the gerbil hippocampus during normal aging
Age-dependent studies on oligodendrocytes, which are the myelinating cells in the central nervous system, have been relatively less investigated. We examined age-dependent changes in Rip immunoreactivity and its protein level in the gerbil hippocampus during normal aging using immunohistochemistry a...
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| Published in: | Neurochemical research 2006-09, Vol.31 (9), p.1119-1125 |
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| Main Authors: | , , , , , , |
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| container_end_page | 1125 |
| container_issue | 9 |
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| container_title | Neurochemical research |
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| creator | Hwang, In Koo Yoo, Ki-Yeon Kim, Dong Shoo Kang, Tae-Cheon Lee, Bong-Hee Kim, Yong-Sun Won, Moo Ho |
| description | Age-dependent studies on oligodendrocytes, which are the myelinating cells in the central nervous system, have been relatively less investigated. We examined age-dependent changes in Rip immunoreactivity and its protein level in the gerbil hippocampus during normal aging using immunohistochemistry and Western blot analysis with Rip antibody, an oligodendrocyte marker. Rip immunoreactivity and its protein level in the hippocampal CA1 region significantly increased at postnatal month 3 (PM 3). Thereafter, they decreased in the hippocampal CA1 region with age. At PM 24, Rip immunoreactive processes in the hippocampal CA1 region markedly decreased in the stratum radiatum. In the hippocampal CA2/3 region and dentate gyrus, the pattern of changes in Rip immunoreactivity and its protein level was similar to those in the hippocampal CA1 region; however, no significant changes were found in the CA2/3 region and dentate gyrus at various age stages. These results indicate that Rip immunoreactivity and protein level in the hippocampal CA1 region decreases significantly at PM 24 compared to the CA2/3 region and dentate gyrus. |
| doi_str_mv | 10.1007/s11064-006-9129-4 |
| format | article |
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We examined age-dependent changes in Rip immunoreactivity and its protein level in the gerbil hippocampus during normal aging using immunohistochemistry and Western blot analysis with Rip antibody, an oligodendrocyte marker. Rip immunoreactivity and its protein level in the hippocampal CA1 region significantly increased at postnatal month 3 (PM 3). Thereafter, they decreased in the hippocampal CA1 region with age. At PM 24, Rip immunoreactive processes in the hippocampal CA1 region markedly decreased in the stratum radiatum. In the hippocampal CA2/3 region and dentate gyrus, the pattern of changes in Rip immunoreactivity and its protein level was similar to those in the hippocampal CA1 region; however, no significant changes were found in the CA2/3 region and dentate gyrus at various age stages. These results indicate that Rip immunoreactivity and protein level in the hippocampal CA1 region decreases significantly at PM 24 compared to the CA2/3 region and dentate gyrus.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/s11064-006-9129-4</identifier><identifier>PMID: 16927168</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Age ; Aging ; Aging - physiology ; Animals ; Antibodies ; Antibodies, Monoclonal ; Biomarkers - metabolism ; Central nervous system ; Dentate gyrus ; Gerbillinae ; Hippocampus ; Hippocampus - cytology ; Hippocampus - metabolism ; Immunohistochemistry ; Male ; Nerve Tissue Proteins - metabolism ; Oligodendrocytes ; Oligodendroglia - cytology ; Oligodendroglia - metabolism ; Proteins ; Stratum radiatum</subject><ispartof>Neurochemical research, 2006-09, Vol.31 (9), p.1119-1125</ispartof><rights>Springer Science+Business Media, LLC 2006</rights><rights>Springer Science+Business Media, Inc. 2006.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-835a4310be0124a4b4f1f5d296ce3890310f9c1a27b9492ebbf519bbaabfdea53</citedby><cites>FETCH-LOGICAL-c385t-835a4310be0124a4b4f1f5d296ce3890310f9c1a27b9492ebbf519bbaabfdea53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16927168$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, In Koo</creatorcontrib><creatorcontrib>Yoo, Ki-Yeon</creatorcontrib><creatorcontrib>Kim, Dong Shoo</creatorcontrib><creatorcontrib>Kang, Tae-Cheon</creatorcontrib><creatorcontrib>Lee, Bong-Hee</creatorcontrib><creatorcontrib>Kim, Yong-Sun</creatorcontrib><creatorcontrib>Won, Moo Ho</creatorcontrib><title>Chronological distribution of Rip immunoreactivity in the gerbil hippocampus during normal aging</title><title>Neurochemical research</title><addtitle>Neurochem Res</addtitle><description>Age-dependent studies on oligodendrocytes, which are the myelinating cells in the central nervous system, have been relatively less investigated. We examined age-dependent changes in Rip immunoreactivity and its protein level in the gerbil hippocampus during normal aging using immunohistochemistry and Western blot analysis with Rip antibody, an oligodendrocyte marker. Rip immunoreactivity and its protein level in the hippocampal CA1 region significantly increased at postnatal month 3 (PM 3). Thereafter, they decreased in the hippocampal CA1 region with age. At PM 24, Rip immunoreactive processes in the hippocampal CA1 region markedly decreased in the stratum radiatum. In the hippocampal CA2/3 region and dentate gyrus, the pattern of changes in Rip immunoreactivity and its protein level was similar to those in the hippocampal CA1 region; however, no significant changes were found in the CA2/3 region and dentate gyrus at various age stages. These results indicate that Rip immunoreactivity and protein level in the hippocampal CA1 region decreases significantly at PM 24 compared to the CA2/3 region and dentate gyrus.</description><subject>Age</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Monoclonal</subject><subject>Biomarkers - metabolism</subject><subject>Central nervous system</subject><subject>Dentate gyrus</subject><subject>Gerbillinae</subject><subject>Hippocampus</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - metabolism</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Oligodendrocytes</subject><subject>Oligodendroglia - cytology</subject><subject>Oligodendroglia - metabolism</subject><subject>Proteins</subject><subject>Stratum radiatum</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkU1LxDAQhoMoun78AC8SFLxVM0maNkdZ_AJBED3HpE13I21Tk1bYf2-WXRAE8TQM88zLDA9Cp0CugJDiOgIQwTNCRCaByozvoBnkBcuEJGwXzQhLUwaSHKDDGD8ISVsU9tEBCEkLEOUMvc-Xwfe-9QtX6RbXLo7BmWl0vse-wS9uwK7rpt4Hq6vRfblxhV2Px6XFCxuMa_HSDYOvdDdMEddTcP0CJ7pLYXqRmmO01-g22pNtPUJvd7ev84fs6fn-cX7zlFWszMesZLnmDIixBCjX3PAGmrymUlSWlekdII2sQNPCSC6pNabJQRqjtWlqq3N2hC43uUPwn5ONo-pcrGzb6t76KSpRljkvcv4vCJJxCVIk8OIX-OGn0KcnFBWCUygpQKLO_6QoFCJ5WkfBBqqCjzHYRg3BdTqsFBC1Vqk2KlVSqdYq1frOs23wZDpb_2xs3bFvTIaZvw</recordid><startdate>200609</startdate><enddate>200609</enddate><creator>Hwang, In Koo</creator><creator>Yoo, Ki-Yeon</creator><creator>Kim, Dong Shoo</creator><creator>Kang, Tae-Cheon</creator><creator>Lee, Bong-Hee</creator><creator>Kim, Yong-Sun</creator><creator>Won, Moo Ho</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200609</creationdate><title>Chronological distribution of Rip immunoreactivity in the gerbil hippocampus during normal aging</title><author>Hwang, In Koo ; Yoo, Ki-Yeon ; Kim, Dong Shoo ; Kang, Tae-Cheon ; Lee, Bong-Hee ; Kim, Yong-Sun ; Won, Moo Ho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-835a4310be0124a4b4f1f5d296ce3890310f9c1a27b9492ebbf519bbaabfdea53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Age</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Monoclonal</topic><topic>Biomarkers - metabolism</topic><topic>Central nervous system</topic><topic>Dentate gyrus</topic><topic>Gerbillinae</topic><topic>Hippocampus</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - metabolism</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Oligodendrocytes</topic><topic>Oligodendroglia - cytology</topic><topic>Oligodendroglia - metabolism</topic><topic>Proteins</topic><topic>Stratum radiatum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, In Koo</creatorcontrib><creatorcontrib>Yoo, Ki-Yeon</creatorcontrib><creatorcontrib>Kim, Dong Shoo</creatorcontrib><creatorcontrib>Kang, Tae-Cheon</creatorcontrib><creatorcontrib>Lee, Bong-Hee</creatorcontrib><creatorcontrib>Kim, Yong-Sun</creatorcontrib><creatorcontrib>Won, Moo Ho</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, In Koo</au><au>Yoo, Ki-Yeon</au><au>Kim, Dong Shoo</au><au>Kang, Tae-Cheon</au><au>Lee, Bong-Hee</au><au>Kim, Yong-Sun</au><au>Won, Moo Ho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronological distribution of Rip immunoreactivity in the gerbil hippocampus during normal aging</atitle><jtitle>Neurochemical research</jtitle><addtitle>Neurochem Res</addtitle><date>2006-09</date><risdate>2006</risdate><volume>31</volume><issue>9</issue><spage>1119</spage><epage>1125</epage><pages>1119-1125</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>Age-dependent studies on oligodendrocytes, which are the myelinating cells in the central nervous system, have been relatively less investigated. We examined age-dependent changes in Rip immunoreactivity and its protein level in the gerbil hippocampus during normal aging using immunohistochemistry and Western blot analysis with Rip antibody, an oligodendrocyte marker. Rip immunoreactivity and its protein level in the hippocampal CA1 region significantly increased at postnatal month 3 (PM 3). Thereafter, they decreased in the hippocampal CA1 region with age. At PM 24, Rip immunoreactive processes in the hippocampal CA1 region markedly decreased in the stratum radiatum. In the hippocampal CA2/3 region and dentate gyrus, the pattern of changes in Rip immunoreactivity and its protein level was similar to those in the hippocampal CA1 region; however, no significant changes were found in the CA2/3 region and dentate gyrus at various age stages. These results indicate that Rip immunoreactivity and protein level in the hippocampal CA1 region decreases significantly at PM 24 compared to the CA2/3 region and dentate gyrus.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>16927168</pmid><doi>10.1007/s11064-006-9129-4</doi><tpages>7</tpages></addata></record> |
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| source | Springer Nature |
| subjects | Age Aging Aging - physiology Animals Antibodies Antibodies, Monoclonal Biomarkers - metabolism Central nervous system Dentate gyrus Gerbillinae Hippocampus Hippocampus - cytology Hippocampus - metabolism Immunohistochemistry Male Nerve Tissue Proteins - metabolism Oligodendrocytes Oligodendroglia - cytology Oligodendroglia - metabolism Proteins Stratum radiatum |
| title | Chronological distribution of Rip immunoreactivity in the gerbil hippocampus during normal aging |
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