Coronary artery calcification, common carotid artery intima-media thickness and aortic pulse wave velocity in patients on peritoneal dialysis

An increasing body of evidence suggests that atherosclerosis in patients with uremia differs from that found in general population in terms of advancement and localization of vascular lesions. It has also been suggested that different non-invasive techniques of vascular system evaluation are designe...

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Published in:International journal of artificial organs 2006-08, Vol.29 (8), p.736-744
Main Authors: Stompór, T, Rajzer, M, Pasowicz, M, Kraśniak, A, Sułowicz, W, Kawecka-Jaszcz, K, Tracz, W, Janda, K, Tabor, B, Kowalczyk-Michałek, M E, Wójcik, K, Konieczyńska, M, Klimeczek, P, Janusz-Grzybowska, E
Format: Article
Language:English
Subjects:
Aorta - physiopathology
Blood Flow Velocity - physiology
Blood Pressure - physiology
Calcinosis - classification
Calcinosis - diagnostic imaging
Carotid Artery Diseases - diagnostic imaging
Carotid Artery Diseases - physiopathology
Carotid Artery, Common - diagnostic imaging
Carotid Artery, Common - physiopathology
Coronary Artery Disease - classification
Coronary Artery Disease - diagnostic imaging
Elasticity
Female
Humans
Male
Middle Aged
Peritoneal Dialysis
Pulsatile Flow - physiology
Tomography, Spiral Computed
Tunica Intima - diagnostic imaging
Tunica Intima - physiopathology
Tunica Media - diagnostic imaging
Tunica Media - physiopathology
Ultrasonography
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Summary:An increasing body of evidence suggests that atherosclerosis in patients with uremia differs from that found in general population in terms of advancement and localization of vascular lesions. It has also been suggested that different non-invasive techniques of vascular system evaluation are designed to show different types of lesions (i.e. vascular calcification, stiffness or 'classical' atherosclerosis). The aim of the study was to search for possible associations between results obtained with three different non-invasive methods of vascular system assessment in three different vascular sites in patients treated with peritoneal dialysis (PD). 61 patients (28 F, 33 M), mean age of 50.4+/-13.6 years, on maintenance PD for a median period of 10 months (range 1-96 months) were included. Coronary artery disease (CAD) was present in 21 subjects. In all subjects coronary artery calcification score (CaSc) using multi-row spiral computed tomography (MSCT), aortic pulse wave velocity (AoPWV) and ultrasound-based common carotid artery intima-media thickness (CCA-IMT) were performed as methods for assessing coronary calcium burden, arterial stiffness and atherosclerosis, respectively. Median value of CaSc equaled 11.5 Agatston units (range 0-5502.8 units). Median AoPWV was 10.4 m/s (range 7.56-18.1 m/s), and median CCA-IMT-0.6 mm (range 0.3-1.0 mm). In 16 patients (26.2%) at least one plaque in at least one common carotid artery was found on ultrasound. CaSc correlated with AoPWV (R=0.32, p
ISSN:0391-3988
1724-6040
DOI:10.1177/039139880602900802