Experimental comparative study of bioactive composite with polymeric matrix for applications to oculoplastic surgery for tissue replacement

To compare two new biomaterials: Composite 10% (Engineering School--Universidade Federal de Minas Gerais-UFMG-Brazil) and Composite 20% (Engineering School--Universidade Federal de Minas Gerais-UFMG-Brazil), with two similar materials as control: Medpor (Porex Surgical Inc.--USA) e Polipore (Homus C...

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Bibliographic Details
Published in:Arquivos brasileiros de oftalmologia 2005-07, Vol.68 (4), p.425-431
Main Authors: França, Valênio Pérez, Figueiredo, Ana Rosa Pimentel de, Vasconcelos, Anilton César, Oréfice, Rodrigo Lambert
Format: Article
Language:Portuguese
Subjects:
Animals
Biocompatible Materials - therapeutic use
Composite Resins - therapeutic use
Materials Testing
Microscopy, Electron, Scanning
Prostheses and Implants - adverse effects
Rabbits
Random Allocation
Reconstructive Surgical Procedures - methods
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Summary:To compare two new biomaterials: Composite 10% (Engineering School--Universidade Federal de Minas Gerais-UFMG-Brazil) and Composite 20% (Engineering School--Universidade Federal de Minas Gerais-UFMG-Brazil), with two similar materials as control: Medpor (Porex Surgical Inc.--USA) e Polipore (Homus Com. Ind. Ltda--BRASIL). In vivo randomized experimental double blind study: a transconjunctival approach was performed in both cartilaginous superior orbital walls of 28 rabbits for 56 implants divided into 4 groups: GI: Composite 10%/Medpor; GII: Composite 10%/Polipore; GIII: Composite 20%/Medpor; GIV: Composite 20%/Polipore. The mean rate for implant time of permanence was 19.7 weeks. The Student's t test was used for statistical analysis. Revealed similar biocompatibility of all materials and none of the implants was extruded; one Composite 20% had partial exposure. Histomorphometry showed a greater bioactivity of the composites with significantly thicker fibrous encapsulation, with more collagen and fibroblasts, exuberant angiogenesis, and a lower inflammatory cell mean compared to controls. The presence of precipitation of a hydroxycarbonate apatite layer, which acts as an implant-tissue bond was confirmed. Composites presented a smaller tissular invasion index of the pores compared to controls. The composites showed a good biocompatibility and some additional advantage over the Medpor and Polipore controls.
ISSN:0004-2749