Homocysteine, vitamin B12, and folic acid in age-related macular degeneration

Hyperhomocysteinemia is considered an independent risk factor for atherosclerosis and thrombosis. The purpose of this study was to evaluate plasma homocysteine, red blood cell folate, plasma folate, and plasma vitamin B12 concentration in patients with exudative age-related macular degeneration (ARM...

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Published in:European journal of ophthalmology 2005-11, Vol.15 (6), p.764-767
Main Authors: Nowak, M, Swietochowska, E, Wielkoszyński, T, Marek, B, Kos-Kudła, B, Szapska, B, Kajdaniuk, D, Głogowska-Szelág, J, Siemińska, L, Ostrowska, Z, Kozioł, H, Klimek, J
Format: Article
Language:English
Subjects:
Aged
Chromatography, High Pressure Liquid
Erythrocytes - metabolism
Female
Folic Acid - blood
Homocysteine - blood
Humans
Hyperhomocysteinemia - blood
Macular Degeneration - blood
Male
Middle Aged
Risk Factors
Vitamin B 12 - blood
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Summary:Hyperhomocysteinemia is considered an independent risk factor for atherosclerosis and thrombosis. The purpose of this study was to evaluate plasma homocysteine, red blood cell folate, plasma folate, and plasma vitamin B12 concentration in patients with exudative age-related macular degeneration (ARMD). The participants of this study included 30 patients aged 60 to 71 years (mean age 66.2+/-3.6) with exudative ARMD. Plasma homocysteine levels were determined by high performance liquid chromatography (HPLC). Red blood cell folate, plasma folate, and plasma vitamin B12 concentration were determined using a standard kit (Dualcount Solid Phase No Boill radioassay kit for B12/folic acid, DPC Diagnostic, USA) by radioassay method. The plasma concentration of Hcy (14.88+/-6.23 micromol/L) in ARMD patients was significantly increased (p
ISSN:1120-6721
1724-6016
DOI:10.1177/112067210501500617