Behavior of intraocular pressure according to cardiorespiratory and hemodynamic effects induced by desflurane in dogs subjected to experimental hypovolemia

To observe the behavior of intraocular pressure according to the cardiopulmonary and hemodynamic effects induced by desflurane in dogs subjected to experimental hypovolemia. Eighteen healthy male and female mongrel dogs, weighing between 10 and 15 kg were used. Hypovolemia was induced by withdrawal...

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Published in:Arquivos brasileiros de oftalmologia 2005-07, Vol.68 (4), p.521-526
Main Authors: Talieri, Ivia Carmem, Honsho, Cristiane dos Santos, Nunes, Newton, Souza, Almir Pereira de, Duque, Juan Carlos
Format: Article
Language:Portuguese
Subjects:
Analysis of Variance
Anesthesia - veterinary
Anesthetics, Inhalation - therapeutic use
Animals
Blood Pressure - drug effects
Blood Pressure - physiology
Cardiac Output - drug effects
Cardiac Output - physiology
Dogs - surgery
Female
Hemodynamics - physiology
Hypovolemia - physiopathology
Hypovolemia - veterinary
Intraocular Pressure - drug effects
Intraocular Pressure - physiology
Isoflurane - analogs & derivatives
Isoflurane - therapeutic use
Male
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Summary:To observe the behavior of intraocular pressure according to the cardiopulmonary and hemodynamic effects induced by desflurane in dogs subjected to experimental hypovolemia. Eighteen healthy male and female mongrel dogs, weighing between 10 and 15 kg were used. Hypovolemia was induced by withdrawal of 40 ml blood/kg body weight. Then anesthesia was induced with desflurane by mask until tracheal intubation was permitted. Intraocular pressure was measured with applanation tonometry. Heart rate, cardiac output, mean arterial pressure, central venous pressure, end-tidal concentration of CO2 and respiratory rate were recorded. Parameters were registered after animal instrumentation and before any procedure in the awake dogs (T0), fifteen minutes after experimental hemorrhage induction (T45), and after thirty minutes of desflurane anesthesia (T75). Intraocular pressure presented direct correlation only with pressure and end-tidal concentration of CO2. It was not possible to establish a correlation between alterations of mean arterial pressure and central venous pressure and intraocular pressure and there was a direct relationship between values of intraocular pressure and values of exhaled CO2.
ISSN:0004-2749