Increased plasma levels of IL-6 in bacteremic periodontis patients after scaling

Bacteremia frequently occurs after dental treatment. Periodontal inflammation may influence the incidence, magnitude and duration of bacteremia. The presence of circulating oral bacteria or bacterial components may induce cytokine synthesis in blood cells, which may contribute to the development or...

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Bibliographic Details
Published in:Journal of clinical periodontology 2006-10, Vol.33 (10), p.724-729
Main Authors: Forner, Lone, Nielsen, Claus Henrik, Bendtzen, Klaus, Larsen, Tove, Holmstrup, Palle
Format: Article
Language:English
Subjects:
Adult
bacteremia
Bacteremia - immunology
Bacteremia - microbiology
Bacteroidaceae Infections - blood
cytokine
Dental Plaque Index
Dental Scaling
Dentistry
Female
Follow-Up Studies
Gingival Hemorrhage - classification
Humans
Interleukin-10 - blood
Interleukin-12 - blood
Interleukin-6 - blood
Interleukin-8 - blood
Male
Middle Aged
Periodontal Attachment Loss - classification
Periodontal Index
Periodontal Pocket - classification
periodontitis
Periodontitis - blood
Prevotella - classification
Streptococcal Infections - blood
Streptococcus - classification
Time Factors
Tumor Necrosis Factor-alpha - analysis
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Summary:Bacteremia frequently occurs after dental treatment. Periodontal inflammation may influence the incidence, magnitude and duration of bacteremia. The presence of circulating oral bacteria or bacterial components may induce cytokine synthesis in blood cells, which may contribute to the development or exacerbation of atherosclerosis. The present study tested the hypothesis that bacteremia occurring after scaling in periodontitis patients results in altered plasma levels of cytokines. Twenty periodontitis patients were subjected to scaling. Blood samples at baseline and at 0.5, 10 and 30 minutes postscaling were examined for bacteremia whereas baseline and eight‐hour postscaling blood samples were examined for the levels of IL‐1β, TNF‐α, IL‐6, IL‐8, IL‐10 and IL‐12p70. IL‐6 levels were significantly increased eight hours after scaling, while IL‐8 was significantly decreased. No systematic changes occurred in the levels of IL‐1β, TNF–α, IL‐10 and IL‐2p70. IL‐6 levels may be increased while IL‐8 may be decreased due to scaling, which may have implications for general health.
ISSN:0303-6979
1600-051X
DOI:10.1111/j.1600-051X.2006.00964.x