Topical antiinflammatory and analgesic activities of Copaifera duckei dwyer

The oleoresin of several Copaifera species is used widely in the Amazonian Region mainly as a topical antiinflammatory and healing agent. The topical analgesic and antiinflammatory activities of Copaifera duckei oleoresin, whose terpenoidal chemical composition has been characterized, are now examin...

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Bibliographic Details
Published in:Phytotherapy research 2005-11, Vol.19 (11), p.946-950
Main Authors: Carvalho, J.C.T, Cascon, V, Possebon, L.S, Morimoto, M.S.S, Cardoso, L.G.V, Kaplan, M.A.C, Gilbert, B
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Analgesics - pharmacology
Analysis of Variance
Animals
Anti-Inflammatory Agents - pharmacology
Biological and medical sciences
copaiba
Copaifera duckei
Croton Oil
Dermatitis - drug therapy
Edema - drug therapy
Fabaceae
General pharmacology
Granuloma, Foreign-Body - drug therapy
Male
Medical sciences
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Rats
Rats, Wistar
terpenes
Terpenes - analysis
topical analgesic activity
topical antiinflammatory activity
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Summary:The oleoresin of several Copaifera species is used widely in the Amazonian Region mainly as a topical antiinflammatory and healing agent. The topical analgesic and antiinflammatory activities of Copaifera duckei oleoresin, whose terpenoidal chemical composition has been characterized, are now examined. Antiinflammatory activity was evaluated in rats using the carrageenin‐induced paw edema and the granuloma tests, and in mice by the croton oil‐induced dermatitis test. Analgesic activity was determined in mice using the writhing test method. In the carrageenin‐induced edema and granuloma tests the oleoresin in a dose of 1802 mg/kg inhibited the edema by 18% and granuloma by 42% (p < 0.05), this last result similar to that observed with dexamethasone. Topical doses of 517 mg/kg, 1035 mg/kg and 1802 mg/kg produced 52%, 58% and 62% (p < 0.05) reduction of the edema induced by croton oil, respectively, and 48%, 56% and 65% inhibition of the writhing process (p < 0.05). These results suggest that the Copaifera duckei oleoresin has topical antiinflammatory and analgesic activities. Copyright © 2005 John Wiley & Sons, Ltd.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.1762