Photodynamic therapy of experimental tumors using 5-aminolevulinic acid

The photodynamic therapy (PDT) of Lewis carcinoma in c57Bl/6 mice and sarcoma 180 in random bred mice was carried out with 5-aminolaevulinic acid (ALA) used as a photosensitizer. It has been shown that ALA-PDT effectively inhibited the growth of Lewis carcinoma and sarcoma 180, decreased the frequen...

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Bibliographic Details
Published in:Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) Ukraine : 1994), 2005, Vol.51 (5), p.65-70
Main Authors: Hamaliia, M F, Kutsenok, V V, Horobets', O B, Lozyns'kyĭ, M O, Borysevych, A M, Kholin, V V
Format: Article
Language:Ukrainian
Subjects:
Aminolevulinic Acid - pharmacology
Animals
Carcinoma, Lewis Lung - pathology
Carcinoma, Lewis Lung - therapy
Mice
Mice, Inbred C57BL
Photochemotherapy
Photosensitizing Agents - pharmacology
Sarcoma 180 - pathology
Sarcoma 180 - therapy
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Summary:The photodynamic therapy (PDT) of Lewis carcinoma in c57Bl/6 mice and sarcoma 180 in random bred mice was carried out with 5-aminolaevulinic acid (ALA) used as a photosensitizer. It has been shown that ALA-PDT effectively inhibited the growth of Lewis carcinoma and sarcoma 180, decreased the frequency of metastatic spreading and the number of metastases to lung in mice with Lewis carcinoma. It is concluded that PDT with ALA is a potentially perspective method of tumor treatment.
ISSN:2522-9028