Changes of urinary nerve growth factor and prostaglandins in male patients with overactive bladder symptom

• Published in: International journal of urology 2005-10, Vol.12 (10), p.875-880
• Main Authors: KIM, JOON CHUL, PARK, EUN YOUNG, HONG, SUNG HOO, SEO, SEONG IL, PARK, YONG HYUN, HWANG, TAE-KON
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers - urine; Enzyme-Linked Immunosorbent Assay; Follow-Up Studies; Humans; Male; Middle Aged; nerve growth factor; Nerve Growth Factor - urine; Prognosis; prostaglandins; Prostaglandins - urine; Severity of Illness Index; Urinary Incontinence - physiopathology; Urinary Incontinence - urine; urinary tract; urine; Urodynamics - physiology
• ISSN: 0919-8172; 1442-2042
• DOI: 10.1111/j.1442-2042.2005.01140.x

Aim:  Nerve growth factor (NGF) and prostaglandins (PG) in the urinary bladder can be affected by pathology of bladder, and this change can be noted in the urine. This study was performed to investigate the changes in urinary NGF and PG in male patient with overactive bladder (OAB) symptoms. Methods:  The study group included 75 male patients with OAB symptoms and 20 males without bladder symptoms as controls. Evaluation included history‐taking, urinalysis, International Prostate Symptom Score (IPSS) and urodynamic study. The NGF, PGE2, PGF2α and PGI2 levels in voided urine were analyzed by enzyme linked immunosorbent assay and these results were compared in control and OAB patients. Also, the urinary levels of NGF and PG were correlated with IPSS score and urodynamic parameters in OAB patients. Results:  The urinary levels of NGF and PGE2 were significantly increased in patients with OAB compared with control (P