Alu elements within human mRNAs are probable microRNA targets

Recently, we reported that four microRNAs show perfect complementarity with MIR/LINE-2 elements within human mRNAs. This finding raises the question of whether microRNAs might also target other genomic repeats and transposable elements. Here, we demonstrate that almost 30 human microRNAs exhibit typ...

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Bibliographic Details
Published in:Trends in genetics 2006-10, Vol.22 (10), p.532-536
Main Authors: Smalheiser, Neil R., Torvik, Vetle I.
Format: Article
Language:English
Subjects:
3' Untranslated Regions
Alu Elements
Base Sequence
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Genic rearrangement. Recombination. Transposable element
Humans
MicroRNAs - genetics
MicroRNAs - metabolism
Models, Genetic
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
RNA, Messenger - chemistry
Sequence Alignment
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Summary:Recently, we reported that four microRNAs show perfect complementarity with MIR/LINE-2 elements within human mRNAs. This finding raises the question of whether microRNAs might also target other genomic repeats and transposable elements. Here, we demonstrate that almost 30 human microRNAs exhibit typical short-seed complementarity with a specific site within Alu elements that is highly conserved within 3′ untranslated regions of human mRNAs. The results suggest that at least some Alu elements within human mRNAs serve as microRNA targets.
ISSN:0168-9525
DOI:10.1016/j.tig.2006.08.007