Primary yolk sac tumor concomitant with carcinosarcoma originating from the endometrium: Case report

A primary yolk sac tumor (YST) with carcinosarcoma originating from the endometrium is extremely rare, to our knowledge, this is the third documented instance. Several hypotheses exist is to its histogenesis. A 65-year-old Japanese woman was diagnosed with a uterine malignancy and underwent surgical...

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Bibliographic Details
Published in:Gynecologic oncology 2006-10, Vol.103 (1), p.368-371
Main Authors: Oguri, Hiroyoshi, Sumitomo, Ruriko, Maeda, Nagamasa, Fukaya, Takao, Moriki, Toshiaki
Format: Article
Language:English
Subjects:
Aged
Carcinosarcoma - pathology
Endodermal sinus tumor
Endodermal Sinus Tumor - pathology
Endometrial Neoplasms - pathology
Endometrium
Female
Histogenesis
Humans
Mullerian mesodermal
Yolk sac tumor
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Summary:A primary yolk sac tumor (YST) with carcinosarcoma originating from the endometrium is extremely rare, to our knowledge, this is the third documented instance. Several hypotheses exist is to its histogenesis. A 65-year-old Japanese woman was diagnosed with a uterine malignancy and underwent surgical treatment and chemotherapy. The postoperative diagnosis was primary carcinosarcoma concomitant with a YST of the uterus. Immunohistochemical staining revealed that the tumor area suspected to be a YST was positive for alpha-fetoprotein. We report a case of carcinosarcoma concomitant with a YST of uterus. This case is the third documented instance of a YST with concomitant with carcinosarcoma originating from the endometrium. The histogenesis in this case is suggests aberrantly differentiated somatic cells.
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2006.04.024