Relationship between clinical factors and neuropsychiatric manifestations in systemic lupus erythematosus

Neuropsychiatric symptoms are often seen in patients with systemic lupus erythematosus (SLE). To investigate the relationship between involvement of the nervous system and clinical factors, including autoantibodies and the activity of SLE, we retrospectively reviewed 25 patients with neuropsychiatri...

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Bibliographic Details
Published in:Clinical rheumatology 2005-10, Vol.24 (5), p.469-475
Main Authors: Shimojima, Yasuhiro, Matsuda, Masayuki, Gono, Takahisa, Ishii, Wataru, Ikeda, Shu-ichi
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Autoantibodies - blood
Autoimmune diseases
Child
Female
Humans
Lupus
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - physiopathology
Lupus Erythematosus, Systemic - psychology
Male
Medical treatment
Middle Aged
Nervous System Diseases - etiology
Nervous System Diseases - physiopathology
Recurrence
Retrospective Studies
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Summary:Neuropsychiatric symptoms are often seen in patients with systemic lupus erythematosus (SLE). To investigate the relationship between involvement of the nervous system and clinical factors, including autoantibodies and the activity of SLE, we retrospectively reviewed 25 patients with neuropsychiatric SLE (NPSLE, mean age: 35.2+/-12.2 years). As controls 37 SLE patients without neuropsychiatric manifestations (mean age: 31.8+/-15.8 years) were employed in this study. At the onset no significant differences were seen in any clinical factors between the patients and the controls except for serum antinuclear antibodies. In relapse, the patients with NPSLE showed significantly lower levels of Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores without neuropsychiatric evaluation (p
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-004-1060-y