Beneficial effects of atorvastatin on myocardial regions with initially low vasodilatory capacity at various stages of coronary artery disease

The aim of this study was to analyse non-invasively the regional effect of therapy with an HMG-CoA reductase inhibitor on myocardial blood flow in patients with coronary artery disease (CAD) with special reference to segments with initially substantially impaired vasodilation. The study included 26...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2005-12, Vol.32 (12), p.1371-1377
Main Authors: Wielepp, Peter, Baller, Detlev, Gleichmann, Ulrich, Pulawski, Ewa, Horstkotte, Dieter, Burchert, Wolfgang
Format: Article
Language:English
Subjects:
Aged
Atorvastatin Calcium
Blood Flow Velocity
Coronary Artery Disease - complications
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - drug therapy
Coronary Circulation - drug effects
Coronary Vessels - diagnostic imaging
Coronary Vessels - drug effects
Disease Progression
Exercise Test
Female
Heptanoic Acids - therapeutic use
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Male
Middle Aged
Pyrroles - therapeutic use
Radionuclide Imaging
Treatment Outcome
Vasodilation - drug effects
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - drug therapy
Ventricular Dysfunction, Left - etiology
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Summary:The aim of this study was to analyse non-invasively the regional effect of therapy with an HMG-CoA reductase inhibitor on myocardial blood flow in patients with coronary artery disease (CAD) with special reference to segments with initially substantially impaired vasodilation. The study included 26 patients with untreated hypercholesterolaemia. Coronary angiography revealed CAD in nine patients with stenosis >50% and wall irregularities or minimal stenosis or =2.0 ml/min/g) and those with abnormal (MBF
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-005-1828-6