Is defective lymphatic drainage a trigger for lymphoid neogenesis?

The progressive organization of cellular infiltrates into functional ectopic germinal centers (i.e. lymphoid neogenesis) has been recently evidenced in various chronic inflammatory diseases. Failure of the immune system to eradicate the targeted antigen(s) is a shared feature of all of the pathologi...

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Bibliographic Details
Published in:Trends in Immunology 2006-10, Vol.27 (10), p.441-445
Main Authors: Thaunat, Olivier, Kerjaschki, Dontjscho, Nicoletti, Antonino
Format: Article
Language:English
Subjects:
Animals
Choristoma - immunology
Choristoma - pathology
Germinal Center - immunology
Germinal Center - pathology
Humans
Immune system
Inflammation - pathology
Lymphatic system
Lymphatic System - immunology
Lymphatic System - pathology
Medical research
Rodents
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Summary:The progressive organization of cellular infiltrates into functional ectopic germinal centers (i.e. lymphoid neogenesis) has been recently evidenced in various chronic inflammatory diseases. Failure of the immune system to eradicate the targeted antigen(s) is a shared feature of all of the pathological situations associated with lymphoid neogenesis. Although necessary, inability of the immune system to eradicate the antigen(s) seems insufficient to trigger lymphoid neogenesis by itself. We propose that both defective lymphatic drainage of the inflamed tissue and enduring local antigenic stimulation are the crucial triggers of the cascade of events leading to lymphoid neogenesis. In turn, ectopic germinal centers prevent the restoration of lymph outflow by diverting inflammation-dependent lymphangiogenesis. Antigens and immune effectors are rerouted towards the neoformed ectopic lymphoid structures. A self-perpetuating feedback loop, which further sustains the development of the local immune response, is now imposed.
ISSN:1471-4906
1471-4981
1365-2567
DOI:10.1016/j.it.2006.08.003