Results from the ARTEMIS DISK Global Antifungal Surveillance Study: a 6.5-Year Analysis of Susceptibilities of Candida and Other Yeast Species to Fluconazole and Voriconazole by Standardized Disk Diffusion Testing

Fluconazolein vitro susceptibility test results for 140,767 yeasts were collectedfrom 127 participating investigators in 39 countries from June 1997through December 2003. Data were collected on 79,343 yeast isolatestested with voriconazole from 2001 through 2003. All investigatorstested clinical yea...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2005-12, Vol.43 (12), p.5848-5859
Main Authors: Pfaller, M. A, Diekema, D. J, Rinaldi, M. G, Barnes, R, Hu, B, Veselov, A. V, Tiraboschi, N, Nagy, E, Gibbs, D. L
Format: Article
Language:English
Subjects:
Antifungal Agents - pharmacology
Candida
Candida - classification
Candida - drug effects
Candida krusei
Drug Resistance, Fungal
Fluconazole - pharmacology
Global Health
Humans
Microbial Sensitivity Tests - methods
Mycology
Population Surveillance
Pyrimidines - pharmacology
Triazoles - pharmacology
Voriconazole
Yeasts - classification
Yeasts - drug effects
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Summary:Fluconazolein vitro susceptibility test results for 140,767 yeasts were collectedfrom 127 participating investigators in 39 countries from June 1997through December 2003. Data were collected on 79,343 yeast isolatestested with voriconazole from 2001 through 2003. All investigatorstested clinical yeast isolates by the CLSI (formerly NCCLS) M44-A diskdiffusion method. Test plates were automatically read and results wererecorded with the BIOMIC Vision Image Analysis System. Species, drug,zone diameter, susceptibility category, and quality control resultswere collected quarterly via e-mail for analysis. Duplicate (the samepatient, same species, and same susceptible-resistant biotype profileduring any 7-day period) and uncontrolled test results were notanalyzed. The 10 most common species of yeasts all showed lessresistance to voriconazole than to fluconazole. Candida kruseishowed the largest difference, with over 70% resistance to fluconazoleand less than 8% to voriconazole. All species of yeasts tested weremore susceptible to voriconazole than to fluconazole, assuming proposedinterpretive breakpoints of [>/=]17 mm (susceptible) and
ISSN:0095-1137
1098-660X
1098-5530
DOI:10.1128/JCM.43.12.5848-5859.2005