Immunohistochemical localization of sodium-dependent L-ascorbic acid transporter 1 protein in rat kidney

Recently, two L-ascorbic acid transporters were identified; sodium-dependent vitamin C transporter (SVCT) 1 and SVCT2. The previous study suggested that SVCT protein might be present on the apical membrane in the straight segment (S3) of proximal tubule. In the present study, SVCT1 immunoreactivity...

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Published in:Histochemistry and cell biology 2006-10, Vol.126 (4), p.491-494
Main Authors: Lee, Ju Hyun, Oh, Chang Seok, Mun, Ga Hee, Kim, Jae Hyup, Chung, Yoon Hee, Hwang, Young Il, Shin, Dong Hoon, Lee, Wang Jae
Format: Article
Language:English
Subjects:
Animals
Immunohistochemistry
Immunology
Kidney - chemistry
Kidneys
Organic Anion Transporters, Sodium-Dependent - analysis
Proteins
Rats
Rodents
Sodium
Sodium-Coupled Vitamin C Transporters
Symporters - analysis
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Summary:Recently, two L-ascorbic acid transporters were identified; sodium-dependent vitamin C transporter (SVCT) 1 and SVCT2. The previous study suggested that SVCT protein might be present on the apical membrane in the straight segment (S3) of proximal tubule. In the present study, SVCT1 immunoreactivity (IR) was observed in the brush border of proximal straight tubules in the medullary ray of renal cortex and the outer stripe of outer medulla, while SVCT2 IR was not localized in any region of the kidney. Since the mechanism of VC reabsorption in the kidney has not been fully elucidated up to the present time, it is meaningful to demonstrate the exact cellular distribution of SVCT protein in the kidney.
ISSN:0948-6143
1432-119X
DOI:10.1007/s00418-006-0186-1