Effect of Distal Protection Device on the Microvascular Integrity in Acute Myocardial Infarction During Primary Percutaneous Coronary Intervention

Background The use of a distal protection device during primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) may preserve the microvascular integrity of the myocardium. Methods and Results A total of 58 consecutive patients with AMI, who had undergone primary PCI wit...

Full description

Saved in:
Bibliographic Details
Published in:Circulation Journal 2006, Vol.70(10), pp.1284-1289
Main Authors: Yoon, Myeong-Ho, Tahk, Seung-Jea, Choi, So-Yeon, Choi, Tae-Young, Choi, Byoung-Joo, Choi, Jung-Hyun, Yoo, Sang-Yong, Ahn, Sung-Gyun, Zheng, Zhen-Guo, Hwang, Gyo-Seung, Shin, Joon-Han
Format: Article
Language:English
Subjects:
Acute myocardial infarction
Adult
Aged
Angioplasty, Balloon, Coronary - adverse effects
Angioplasty, Balloon, Coronary - methods
Blood Flow Velocity
Coronary Vessels - physiopathology
Distal protection device
Equipment and Supplies - standards
Female
Humans
Intracoronary Doppler wire
Male
Microcirculation - physiopathology
Microvascular circulation
Middle Aged
Myocardial Infarction - therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The use of a distal protection device during primary percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) may preserve the microvascular integrity of the myocardium. Methods and Results A total of 58 consecutive patients with AMI, who had undergone primary PCI within 24 h after onset, were enrolled (30 patients with the PercuSurge GuardWire ® System, 28 without). The coronary flow velocity reserve was not different between the 2 groups. In patients with a distal protection device, the post-PCI Thrombolysis In Myocardial Infarction myocardial perfusion grades (TMP) were more favorable (TMP 0/1: 13.3%, TMP 2: 23.3%, TMP 3: 63.4% vs TMP 0/1: 35.7%, TMP 2: 35.7%, TMP 3: 28.6%, p=0.023). These patients also exhibited lower basal and hyperemic microvascular resistance index levels (4.33±2.22 vs 5.55±2.36 mmHg · cm-1 · s, p=0.047; 2.39±1.40 vs 3.14±1.36 mmHg · cm-1 · s, p=0.045, respectively), and longer basal diastolic deceleration time (679±273 vs 519±289 ms, p=0.035) after PCI. Conclusion Distal protection with the PercuSurge GuardWire® system may effectively preserve the microvascular integrity of the myocardium during primary PCI in AMI patients. (Circ J 2006; 70: 1284 - 1289)
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.70.1284