A novel HLA-B2730 allele found in a Slovene patient affected with IgA nephropathy

Summary A novel allele HLA‐B*2730 and the haplotype HLA‐A*03‐B*2730‐Cw*02‐DRB1*16‐DRB5 have been found in a Slovene patient and his mother. The exon 2 sequence is identical to that of HLA‐B*2702, and the exon 3 sequence is identical to that of HLA‐B*2719. A possible mechanism for the generation of B...

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Bibliographic Details
Published in:International Journal of Immunogenetics 2006-10, Vol.33 (5), p.371-373
Main Authors: Vidan-Jeras, B., Kunilo, S., Fae, I., Kandus, A., Fischer, G. F.
Format: Article
Language:English
Subjects:
Adult
Alleles
Amino Acid Sequence
Female
Glomerulonephritis, IGA - genetics
Glomerulonephritis, IGA - surgery
Haplotypes
Histocompatibility Testing
HLA-B Antigens - genetics
HLA-B27 Antigen
Homozygote
Humans
Male
Molecular Sequence Data
Sequence Alignment
Transplantation Immunology
Waiting Lists
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Description
Summary:Summary A novel allele HLA‐B*2730 and the haplotype HLA‐A*03‐B*2730‐Cw*02‐DRB1*16‐DRB5 have been found in a Slovene patient and his mother. The exon 2 sequence is identical to that of HLA‐B*2702, and the exon 3 sequence is identical to that of HLA‐B*2719. A possible mechanism for the generation of B*2730 is a gene conversion event.
ISSN:1744-3121
1744-313X
1365-2370
DOI:10.1111/j.1744-313X.2006.00629.x