General versus spinal anesthesia with different forms of sedation in patients undergoing radical retropubic prostatectomy: Results of a prospective, randomized study

Aim: To assess the impact of spinal anesthesia (SpA) combined with three different forms of conscious sedation on intraoperative and postoperative outcome in patients undergoing radical retropubic prostatectomy (RRP) for organ confined prostate cancer (pCa). Methods: A total of 121 consecutive patie...

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Bibliographic Details
Published in:International journal of urology 2006-09, Vol.13 (9), p.1185-1190
Main Authors: SALONIA, ANDREA, SUARDI, NAZARENO, CRESCENTI, ANTONELLA, COLOMBO, RENZO, RIGATTI, PATRIZIO, MONTORSI, FRANCESCO
Format: Article
Language:English
Subjects:
Adenocarcinoma - surgery
Aged
Anesthesia Recovery Period
Anesthesia, General - methods
Anesthesia, Spinal - methods
Blood Loss, Surgical
Conscious Sedation - methods
Diazepam - administration & dosage
general anesthesia
Humans
Hypnotics and Sedatives - administration & dosage
Intraoperative Complications
Male
Midazolam - administration & dosage
Middle Aged
Postoperative Complications
Preanesthetic Medication
Propofol - administration & dosage
Prospective Studies
prostate cancer
Prostatectomy
Prostatic Neoplasms - surgery
radical prostatectomy
sedation
spinal anesthesia
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Summary:Aim: To assess the impact of spinal anesthesia (SpA) combined with three different forms of conscious sedation on intraoperative and postoperative outcome in patients undergoing radical retropubic prostatectomy (RRP) for organ confined prostate cancer (pCa). Methods: A total of 121 consecutive patients with pCa undergoing RRP were randomized into four groups. They were randomized as follows: group 1 (general anesthesia: 34 patients), group 2 (lumbar 2 to lumbar 3 interspace SpA with diazepam as sedative agent: 28), group 3 (SpA with propofol: 30), and group 4 (SpA with midazolam: 29). Intraoperative and perioperative parameters were collected. Results: The present study showed that muscle relaxation throughout RRP was not different in the four groups; bleeding was significantly (P = 0.04) lower with SpA, regardless of the form of sedation. Group 3 patients reported the best postoperative oxygen saturation percentage by pulse oximetry and sedation score (P = 0.02; d.f. = 3 and P 
ISSN:0919-8172
1442-2042
DOI:10.1111/j.1442-2042.2006.01524.x