Detection of hepatic metastasis: Manganese- and ferucarbotran-enhanced MR imaging

To compare the mangafodipir trisodium (MnDPDP)-enhanced and ferucarbotran-enhanced magnetic resonance imaging (MRI) for the detection of hepatic metastases. Twenty patients with known hepatic metastasis underwent MR imaging using mangafodipir trisodium and ferucarbotran in at least 1-day intervals....

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Bibliographic Details
Published in:European journal of radiology 2006-10, Vol.60 (1), p.84-90
Main Authors: Choi, Jin-Young, Kim, Myeong-Jin, Kim, Joo Hee, Kim, Seung Hyoung, Ko, Heung-Kyu, Lim, Joon Seok, Oh, Young Taik, Chung, Jae-Joon, Yoo, Hyung Sik, Lee, Jong Tae, Kim, Ki Whang
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Contrast agent
Contrast Media
Dextrans
Edetic Acid - analogs & derivatives
Female
Ferrosoferric Oxide
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Image Enhancement - methods
Iron
Liver
Liver Neoplasms - diagnosis
Liver Neoplasms - secondary
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Magnetic Resonance Imaging - methods
Magnetite Nanoparticles
Male
Medical sciences
Metastasis
Middle Aged
MRI
Oxides
Pyridoxal Phosphate - analogs & derivatives
Reproducibility of Results
Sensitivity and Specificity
Tumors
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Summary:To compare the mangafodipir trisodium (MnDPDP)-enhanced and ferucarbotran-enhanced magnetic resonance imaging (MRI) for the detection of hepatic metastases. Twenty patients with known hepatic metastasis underwent MR imaging using mangafodipir trisodium and ferucarbotran in at least 1-day intervals. Thirty-eight metastases were confirmed either histologically or clinically. Two radiologists independently reviewed the MnDPDP-enhanced and ferucarbotran-enhanced sets in a random order. The sensitivity and accuracy of lesion detection and the ability to distinguish a benign lesion from a malignant lesion were compared by the areas (Az) under the receiver operating characteristic (ROC) curve. The lesion-liver contrast-to-noise ratios (CNR) were compared by paired t-test. The overall accuracy for detecting metastases was not significantly different between the MnDPDP set (Az = 0.912 and 0.913 for reader 1 and 2, respectively) and the SPIO set (Az = 0.920 and 0.950). The CNR at the MnDPDP-enhanced images and the SPIO-enhanced images were not significantly different ( P = 0.146). Both MnDPDP- and ferucarbotran-enhanced MRI have a comparable accuracy in detecting hepatic metastasis.
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2006.06.016