Characterization of Architecture Signals in Proteins

A quantitative, property-based approach to protein sequence analysis is presented, grounded in Fourier analysis and signal-processing methodologies. The resulting tools are applied to four protein structure families. We demonstrate the existence of architecture-specific, large amplitude periodicitie...

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Bibliographic Details
Published in:The journal of physical chemistry. B 2006-09, Vol.110 (38), p.18771-18778
Main Author: Rackovsky, S
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Fourier Analysis
Protein Folding
Proteins - chemistry
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Summary:A quantitative, property-based approach to protein sequence analysis is presented, grounded in Fourier analysis and signal-processing methodologies. The resulting tools are applied to four protein structure families. We demonstrate the existence of architecture-specific, large amplitude periodicities in amino acid properties encoded in the sequences of proteins. These signals, whose statistical significance we establish, occur at well-defined wavenumbers, but are expressed in different physical properties in the various proteins which fold to a common architecture. This result explains the long-known convergence of unrelated sequences to a common fold. It is further suggested that these results provide a physical basis for the experimental observation that unrelated sequences that adopt similar architectures fold with similar rates.
ISSN:1520-6106
1520-5207
DOI:10.1021/jp0575097