Effects of Ge Gen Decoction on PGE2 Content and COX Activity in the Degenarated Cervical Intervertebral Discs of Rats

After the rat model of cervical spondylosis was developed for 6 months, the PGE2 content and COX activity in the cervical intervertebral discs were determined respectively by radioimmunoassay and catalytic activity assay. The results indicated that the PGE2 content and COX activity in the model rat...

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Bibliographic Details
Published in:Journal of traditional Chinese medicine 2005-09, Vol.25 (3), p.222-225
Main Author: 周军 方素萍 霍海如 齐云 郭淑英 姜廷良 施杞 王友京
Format: Article
Language:English
Subjects:
Animals
Cervical Vertebrae
Cyclooxygenase 1 - metabolism
Cyclooxygenase 2 - metabolism
Dinoprostone - metabolism
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Female
Intervertebral Disc - metabolism
Male
PGE2
Phytotherapy
Prostaglandin-Endoperoxide Synthases - metabolism
Rats
Rats, Sprague-Dawley
Spinal Osteophytosis - drug therapy
中医药疗法
子宫疾病
环氧合酶
酶活性
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Summary:After the rat model of cervical spondylosis was developed for 6 months, the PGE2 content and COX activity in the cervical intervertebral discs were determined respectively by radioimmunoassay and catalytic activity assay. The results indicated that the PGE2 content and COX activity in the model rat increased significantly, and that Ge Gen Decoction could down-regulate the PGE2 content and inhibit COX activity. This is possibly one of the mechanisms of Ge Gen Decoction for treatinz cervical spondylosis.
ISSN:0255-2922