Resting calcium influx in airway smooth muscle

Plasma membrane Ca 2+ leak remains the most uncertain of the cellular Ca 2+ regulation pathways. During passive Ca 2+ influx in non-stimulated smooth muscle cells, basal activity of constitutive Ca 2+ channels seems to be involved. In vascular smooth muscle, the 3 following Ca 2+ entry pathways cont...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology 2005-08, Vol.83 (8-9), p.717-723
Main Authors: Montano, Luis M, Bazan-Perkins, Blanca
Format: Article
Language:English
Subjects:
Air breathing
Animals
Biological and medical sciences
Calcium (intracellular)
Calcium - metabolism
Calcium channels
Calcium channels (voltage-gated)
Calcium influx
Fundamental and applied biological sciences. Psychology
Humans
Leak channels
Membrane potential
Membrane Potentials
Muscle, Smooth - metabolism
Muscle, Smooth - physiology
Plasma membranes
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Respiratory tract
Smooth muscle
Trachea - metabolism
Vertebrates: respiratory system
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Summary:Plasma membrane Ca 2+ leak remains the most uncertain of the cellular Ca 2+ regulation pathways. During passive Ca 2+ influx in non-stimulated smooth muscle cells, basal activity of constitutive Ca 2+ channels seems to be involved. In vascular smooth muscle, the 3 following Ca 2+ entry pathways contribute to this phenomenon: (i) via voltage-dependent Ca 2+ channels, (ii) receptor gated Ca 2+ channels, and (iii) store operated Ca 2+ channels, although, in airway smooth muscle it seems only 2 passive Ca 2+ influx pathways are implicated, one sensitive to SKF 96365 (receptor gated Ca 2+ channels) and the other to Ni 2+ (store operated Ca 2+ channels). Resting Ca 2+ entry could provide a sufficient amount of Ca 2+ and contribute to resting intracellular Ca 2+ concentration ([Ca 2+ ] i ), maintenance of the resting membrane potential, myogenic tone, and sarcoplasmic reticulum-Ca 2+ refilling. However, further research, especially in airway smooth muscle, is required to better explore the physiological role of this passive Ca 2+ influx pathway as it could be involved in airway hyperresponsiveness.Key words: basal Ca 2+ entry, constitutive Ca 2+ channels, airway and vascular smooth muscle, SKF 96365, Ni 2+ .
ISSN:0008-4212
1205-7541
DOI:10.1139/y05-063