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Relationship of androgens to insulin resistance and chronic inflammation in morbidly obese premenopausal women: studies before and after vertical banded gastroplasty
Morbid obesity is associated with insulin resistance (IR), type 2 diabetes, lipid abnormalities, and hypertension. The association of obesity with increased androgen production and low concentrations of sex hormone-binding globulin (SHBG) in women has been demonstrated as well as a strong associatio...
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| Published in: | Obesity surgery 2006-09, Vol.16 (9), p.1214-1220 |
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| container_issue | 9 |
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| container_title | Obesity surgery |
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| creator | Kopp, Hans-Peter Krzyzanowska, Katharina Schernthaner, Gerit-Holger Kriwanek, Stefan Schernthaner, Guntram |
| description | Morbid obesity is associated with insulin resistance (IR), type 2 diabetes, lipid abnormalities, and hypertension. The association of obesity with increased androgen production and low concentrations of sex hormone-binding globulin (SHBG) in women has been demonstrated as well as a strong association of androgens with markers of inflammation such as high-sensitive C-reactive protein (hsCRP). Because weight loss results in a significant decrease in cardiovascular risk factors, IR and inflammation, we questioned a possible interrelationship between androgens, IR and inflammation in a prospective study with 43 morbidly obese female patients undergoing bariatric surgery.
SHBG, dehydroepiandrosterone-sulfate (DHEA-S), and insulin were measured by ELISA, cortisol by fluorescence polarization immunoassay, androstendione by RIA, and testosterone by electrochemiluminescence immunoassay. The free androgen index (FAI) was calculated as the total testosterone/SHBG ratio. High sensitivity assays were used to obtain concentrations of fasting hsCRP, Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).
Weight loss resulted in a significant increase in SHBG (17+/-12 vs 70+/-30 nmol/l, P |
| doi_str_mv | 10.1381/096089206778392130 |
| format | article |
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SHBG, dehydroepiandrosterone-sulfate (DHEA-S), and insulin were measured by ELISA, cortisol by fluorescence polarization immunoassay, androstendione by RIA, and testosterone by electrochemiluminescence immunoassay. The free androgen index (FAI) was calculated as the total testosterone/SHBG ratio. High sensitivity assays were used to obtain concentrations of fasting hsCRP, Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).
Weight loss resulted in a significant increase in SHBG (17+/-12 vs 70+/-30 nmol/l, P<0.0001). Serum concentrations of androstendione, total testosterone, DHEA-S and the FAI decreased significantly (2.05+/-0.78 vs 1.40+/-0.54 ng/ml, P<0.0001; 1.88+/-0.84 vs 1.16+/-0.57 nmol/L, P<0.0001; 1.72+/-0.86 vs 1.49+/-0.78 microg/ml, P<0.01; 0.15+/-0.10 vs 0.02+/-0.01, P<0.0001; respectively). Preoperatively and postoperatively, no association between androgens and IR, chronic subclinical inflammation and lipid parameters could be observed.
Massive weight loss induced by bariatric surgery is associated with a significant reduction of androgen concentrations but not related to the concomitant decline of chronic inflammation, IR, glucose and lipid abnormalities in premenopausal morbidly obese women.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1381/096089206778392130</identifier><identifier>PMID: 16989707</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Adult ; C-Reactive Protein - metabolism ; Female ; Follow-Up Studies ; Gastrointestinal surgery ; Gastroplasty ; Humans ; Insulin resistance ; Insulin Resistance - physiology ; Interleukin-6 - blood ; Middle Aged ; Obesity ; Obesity, Morbid - blood ; Obesity, Morbid - surgery ; Premenopause - blood ; Prospective Studies ; Sex Hormone-Binding Globulin - metabolism ; Testosterone ; Testosterone Congeners - blood ; Weight Loss - physiology</subject><ispartof>Obesity surgery, 2006-09, Vol.16 (9), p.1214-1220</ispartof><rights>Springer 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c328t-31d8e87f7d5fce12c329ca58f5bd490b9bd659d9cd37270dccc37e8bd0c1de7f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16989707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kopp, Hans-Peter</creatorcontrib><creatorcontrib>Krzyzanowska, Katharina</creatorcontrib><creatorcontrib>Schernthaner, Gerit-Holger</creatorcontrib><creatorcontrib>Kriwanek, Stefan</creatorcontrib><creatorcontrib>Schernthaner, Guntram</creatorcontrib><title>Relationship of androgens to insulin resistance and chronic inflammation in morbidly obese premenopausal women: studies before and after vertical banded gastroplasty</title><title>Obesity surgery</title><addtitle>Obes Surg</addtitle><description>Morbid obesity is associated with insulin resistance (IR), type 2 diabetes, lipid abnormalities, and hypertension. The association of obesity with increased androgen production and low concentrations of sex hormone-binding globulin (SHBG) in women has been demonstrated as well as a strong association of androgens with markers of inflammation such as high-sensitive C-reactive protein (hsCRP). Because weight loss results in a significant decrease in cardiovascular risk factors, IR and inflammation, we questioned a possible interrelationship between androgens, IR and inflammation in a prospective study with 43 morbidly obese female patients undergoing bariatric surgery.
SHBG, dehydroepiandrosterone-sulfate (DHEA-S), and insulin were measured by ELISA, cortisol by fluorescence polarization immunoassay, androstendione by RIA, and testosterone by electrochemiluminescence immunoassay. The free androgen index (FAI) was calculated as the total testosterone/SHBG ratio. High sensitivity assays were used to obtain concentrations of fasting hsCRP, Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).
Weight loss resulted in a significant increase in SHBG (17+/-12 vs 70+/-30 nmol/l, P<0.0001). Serum concentrations of androstendione, total testosterone, DHEA-S and the FAI decreased significantly (2.05+/-0.78 vs 1.40+/-0.54 ng/ml, P<0.0001; 1.88+/-0.84 vs 1.16+/-0.57 nmol/L, P<0.0001; 1.72+/-0.86 vs 1.49+/-0.78 microg/ml, P<0.01; 0.15+/-0.10 vs 0.02+/-0.01, P<0.0001; respectively). Preoperatively and postoperatively, no association between androgens and IR, chronic subclinical inflammation and lipid parameters could be observed.
Massive weight loss induced by bariatric surgery is associated with a significant reduction of androgen concentrations but not related to the concomitant decline of chronic inflammation, IR, glucose and lipid abnormalities in premenopausal morbidly obese women.</description><subject>Adult</subject><subject>C-Reactive Protein - metabolism</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastrointestinal surgery</subject><subject>Gastroplasty</subject><subject>Humans</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - physiology</subject><subject>Interleukin-6 - blood</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - surgery</subject><subject>Premenopause - blood</subject><subject>Prospective Studies</subject><subject>Sex Hormone-Binding Globulin - metabolism</subject><subject>Testosterone</subject><subject>Testosterone Congeners - blood</subject><subject>Weight Loss - physiology</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNplkc2KFTEQhYMozp3RF3AhwYW71vxMdxJ3MugoDAii6yY_lZkM6aRN0g73gXxPc70XBF0VVfWdQ1EHoReUvKFc0rdETUQqRiYhJFeMcvII7aggciCXTD5GuwMwdIKfofNa7wlhdGLsKTqjk5JKELFDv75C1C3kVO_CirPHOrmSbyFV3DIOqW4xJFyghtp0snDYY3tXcgq2r33Uy_JH3xu85GKCi3ucDVTAa4EFUl71VnXED7k373BtmwtQsQGfy9FO-wYF_4TSgu2g6TNw-FbXVvIae9k_Q0-8jhWen-oF-v7xw7erT8PNl-vPV-9vBsuZbAOnToIUXrjRW6CsT5XVo_SjcZeKGGXcNCqnrOOCCeKstVyANI5Y6kB4foFeH33Xkn9sUNu8hGohRp0gb3WepJTjyGkHX_0D3uetpH7bLBml_f-CdYgdIVtyrQX8vJaw6LKfKZkPCc7_J9hFL0_Om1nA_ZWcIuO_ATHFm44</recordid><startdate>200609</startdate><enddate>200609</enddate><creator>Kopp, Hans-Peter</creator><creator>Krzyzanowska, Katharina</creator><creator>Schernthaner, Gerit-Holger</creator><creator>Kriwanek, Stefan</creator><creator>Schernthaner, Guntram</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200609</creationdate><title>Relationship of androgens to insulin resistance and chronic inflammation in morbidly obese premenopausal women: studies before and after vertical banded gastroplasty</title><author>Kopp, Hans-Peter ; Krzyzanowska, Katharina ; Schernthaner, Gerit-Holger ; Kriwanek, Stefan ; Schernthaner, Guntram</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c328t-31d8e87f7d5fce12c329ca58f5bd490b9bd659d9cd37270dccc37e8bd0c1de7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>C-Reactive Protein - metabolism</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastrointestinal surgery</topic><topic>Gastroplasty</topic><topic>Humans</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - physiology</topic><topic>Interleukin-6 - blood</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - surgery</topic><topic>Premenopause - blood</topic><topic>Prospective Studies</topic><topic>Sex Hormone-Binding Globulin - metabolism</topic><topic>Testosterone</topic><topic>Testosterone Congeners - blood</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kopp, Hans-Peter</creatorcontrib><creatorcontrib>Krzyzanowska, Katharina</creatorcontrib><creatorcontrib>Schernthaner, Gerit-Holger</creatorcontrib><creatorcontrib>Kriwanek, Stefan</creatorcontrib><creatorcontrib>Schernthaner, Guntram</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kopp, Hans-Peter</au><au>Krzyzanowska, Katharina</au><au>Schernthaner, Gerit-Holger</au><au>Kriwanek, Stefan</au><au>Schernthaner, Guntram</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of androgens to insulin resistance and chronic inflammation in morbidly obese premenopausal women: studies before and after vertical banded gastroplasty</atitle><jtitle>Obesity surgery</jtitle><addtitle>Obes Surg</addtitle><date>2006-09</date><risdate>2006</risdate><volume>16</volume><issue>9</issue><spage>1214</spage><epage>1220</epage><pages>1214-1220</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Morbid obesity is associated with insulin resistance (IR), type 2 diabetes, lipid abnormalities, and hypertension. The association of obesity with increased androgen production and low concentrations of sex hormone-binding globulin (SHBG) in women has been demonstrated as well as a strong association of androgens with markers of inflammation such as high-sensitive C-reactive protein (hsCRP). Because weight loss results in a significant decrease in cardiovascular risk factors, IR and inflammation, we questioned a possible interrelationship between androgens, IR and inflammation in a prospective study with 43 morbidly obese female patients undergoing bariatric surgery.
SHBG, dehydroepiandrosterone-sulfate (DHEA-S), and insulin were measured by ELISA, cortisol by fluorescence polarization immunoassay, androstendione by RIA, and testosterone by electrochemiluminescence immunoassay. The free androgen index (FAI) was calculated as the total testosterone/SHBG ratio. High sensitivity assays were used to obtain concentrations of fasting hsCRP, Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha).
Weight loss resulted in a significant increase in SHBG (17+/-12 vs 70+/-30 nmol/l, P<0.0001). Serum concentrations of androstendione, total testosterone, DHEA-S and the FAI decreased significantly (2.05+/-0.78 vs 1.40+/-0.54 ng/ml, P<0.0001; 1.88+/-0.84 vs 1.16+/-0.57 nmol/L, P<0.0001; 1.72+/-0.86 vs 1.49+/-0.78 microg/ml, P<0.01; 0.15+/-0.10 vs 0.02+/-0.01, P<0.0001; respectively). Preoperatively and postoperatively, no association between androgens and IR, chronic subclinical inflammation and lipid parameters could be observed.
Massive weight loss induced by bariatric surgery is associated with a significant reduction of androgen concentrations but not related to the concomitant decline of chronic inflammation, IR, glucose and lipid abnormalities in premenopausal morbidly obese women.</abstract><cop>United States</cop><pub>Springer Nature B.V</pub><pmid>16989707</pmid><doi>10.1381/096089206778392130</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult C-Reactive Protein - metabolism Female Follow-Up Studies Gastrointestinal surgery Gastroplasty Humans Insulin resistance Insulin Resistance - physiology Interleukin-6 - blood Middle Aged Obesity Obesity, Morbid - blood Obesity, Morbid - surgery Premenopause - blood Prospective Studies Sex Hormone-Binding Globulin - metabolism Testosterone Testosterone Congeners - blood Weight Loss - physiology |
| title | Relationship of androgens to insulin resistance and chronic inflammation in morbidly obese premenopausal women: studies before and after vertical banded gastroplasty |
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