Antibody levels to Bordetella pertussis in 10-yr-old children with atopy and atopic asthma

Suboptimal immune responses to vaccination have been suggested among atopic infants. The aim of this study was to assess the influence of atopy and atopic asthma on the humoral response to Bordetella pertussis vaccination. Immunoglobulin (Ig)G and IgA specific antibodies were measured by enzyme link...

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Bibliographic Details
Published in:Pediatric allergy and immunology 2005-12, Vol.16 (8), p.637-640
Main Authors: Blanco-Quiros, Alfredo, Garcia-Marcos, Luis, Garrote, Jose A., Martinez-Torres, Antonia E., Leon, Alberto
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - blood
asthma
Asthma - immunology
atopy
Biological and medical sciences
Bordetella pertussis
Bordetella pertussis - immunology
Child
children
Chronic obstructive pulmonary disease, asthma
Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage
Humans
Hypersensitivity, Immediate - immunology
Immunoglobulin A - blood
immunoglobulin E
Immunoglobulin E - blood
Immunoglobulin G - blood
Immunopathology
Medical sciences
Pneumology
serology
Skin Tests
vaccines
Whooping Cough - prevention & control
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Summary:Suboptimal immune responses to vaccination have been suggested among atopic infants. The aim of this study was to assess the influence of atopy and atopic asthma on the humoral response to Bordetella pertussis vaccination. Immunoglobulin (Ig)G and IgA specific antibodies were measured by enzyme linked‐immunosorbent assay in 102, 10‐yr‐old atopic children (66 of them also being asthmatics) and compared with 76 non‐atopic and 53 non‐atopic non‐asthmatic controls of similar age. The levels of antibodies and the percentage of positives to B. pertussis were comparable in all groups. Children with a very high total serum immunoglobulin (Ig)E (Percentile (Pct) > 90th) showed higher (p = 0.01) IgG pertussis antibodies than children with very low serum IgE (Pct 
ISSN:0905-6157
1399-3038
DOI:10.1111/j.1399-3038.2005.00331.x