Functional neuroimaging with MEG: Normative language profiles

The reliability of language-specific brain activation profiles was assessed using Magnetoencephalography (MEG) in five experiments involving ninety-seven normal volunteers of both genders ranging in age from seven to eighty-four years. MEG data were analyzed with a fully automated method to eliminat...

Full description

Saved in:
Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2006-10, Vol.33 (1), p.326-342
Main Authors: Papanicolaou, A.C., Pazo-Alvarez, P., Castillo, E.M., Billingsley-Marshall, R.L., Breier, J.I., Swank, P.R., Buchanan, S., McManis, M., Clear, T., Passaro, A.D.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Aged, 80 and over
Aging - psychology
Brain
Brain - physiology
Brain Mapping
Child
Data Interpretation, Statistical
Diagnostic Imaging
Electric currents
Experiments
Female
Functional Laterality - physiology
Functional neuroimaging
Gender
Humans
Language
Linguistics
Magnetic fields
Magnetoencephalography
Male
Middle Aged
Norms
Photic Stimulation
Psychomotor Performance - physiology
Reading
Recognition (Psychology) - physiology
Reproducibility of Results
Sex Characteristics
Speech Perception
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The reliability of language-specific brain activation profiles was assessed using Magnetoencephalography (MEG) in five experiments involving ninety-seven normal volunteers of both genders ranging in age from seven to eighty-four years. MEG data were analyzed with a fully automated method to eliminate subjective judgments in the process of deriving the activation profiles. Across all experiments, profiles were characterized by significant bilateral activity centered in the superior temporal gyrus, and in activity lateralized to the left middle temporal gyrus. These features were invariant across age, gender, variation in task characteristics, and mode of stimulus presentation. The absolute amount of activation, however, did decline with age in the auditory tasks. Moreover, contrary to the commonly held belief that left hemisphere dominance for language is greater in men than in women, our data revealed an opposite albeit a not consistently significant trend.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2006.06.020