Efficient Polymer-Assisted Strategy for the Deprotection of Protected Oligosaccharides

New strategies in sugar synthesis: A prelinker containing a dihydropyranyl moiety and an activated ester can be attached to a sugar, which is then loaded onto an amino‐modified support by amidation. Standard protecting‐group manipulations are possible. Final cleavage of the linker under mildly acidi...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2006-09, Vol.45 (38), p.6349-6352
Main Authors: Tanaka, Hiroshi, Ishida, Tadasuke, Matoba, Nobuatsu, Tsukamoto, Hirokazu, Yamada, Haruo, Takahashi, Takashi
Format: Article
Language:English
Subjects:
Birch reduction
Carbohydrate Conformation
Carbohydrate Sequence
Chromatography, High Pressure Liquid
glycoconjugates
glycosylation
Molecular Sequence Data
oligosaccharides
Oligosaccharides - chemistry
Polymers - chemistry
solid-phase synthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:New strategies in sugar synthesis: A prelinker containing a dihydropyranyl moiety and an activated ester can be attached to a sugar, which is then loaded onto an amino‐modified support by amidation. Standard protecting‐group manipulations are possible. Final cleavage of the linker under mildly acidic conditions provides the fully deprotected oligosaccharides. TFA=trifluoroacetic acid.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200601128