Coumarinylmethyl Esters for Ultrafast Release of High Concentrations of Cyclic Nucleotides upon One- and Two-Photon Photolysis

Shedding light: Efficient activation of cyclic nucleoside monophosphates (cNMPs) can be achieved upon one‐ and two‐photon flash photolysis of novel photolabile coumarinylmethyl esters of cAMP and cGMP (A=adenosine, G=guanosine) as well as their 8‐bromo‐substituted derivatives. The phototriggers show...

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Published in:Angewandte Chemie International Edition 2005-12, Vol.44 (48), p.7887-7891
Main Authors: Hagen, Volker, Dekowski, Brigitte, Nache, Vasilica, Schmidt, Reinhard, Geißler, Daniel, Lorenz, Dorothea, Eichhorst, Jenny, Keller, Sandro, Kaneko, Hiroshi, Benndorf, Klaus, Wiesner, Burkhard
Format: Article
Language:English
Subjects:
Animals
Cell Line
Coumarins - chemical synthesis
Coumarins - chemistry
Cyclic Nucleotide-Gated Cation Channels
Esters - chemistry
Humans
ion channels
Ion Channels - genetics
Ion Channels - metabolism
Molecular Structure
nucleotides
Nucleotides, Cyclic - chemistry
Oocytes - metabolism
Patch-Clamp Techniques
photoactivatable compounds
Photolysis
Photons
signal transduction
Time Factors
Xenopus
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Summary:Shedding light: Efficient activation of cyclic nucleoside monophosphates (cNMPs) can be achieved upon one‐ and two‐photon flash photolysis of novel photolabile coumarinylmethyl esters of cAMP and cGMP (A=adenosine, G=guanosine) as well as their 8‐bromo‐substituted derivatives. The phototriggers show high solubility in water and permit space‐ and time‐resolved investigations of the molecular mechanisms of cyclic nucleotide dependent processes.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200502411