Syntheses around the Transglycosylation Step in Peptidoglycan Biosynthesis

The problem of antibiotic resistance demands development of anti-infectives with novel modes of action. It is hoped that the present review demonstrates the transglycosylation reaction in peptidoglycan biosynthesis to be a promising target for new anti-infectives for a number of reasons.

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Bibliographic Details
Published in:Chemical reviews 2005-12, Vol.105 (12), p.4610-4660
Main Author: Welzel, Peter
Format: Article
Language:English
Subjects:
Antibiotics
Carbohydrate Conformation
Carbohydrate Sequence
Chemical synthesis
Cyclization
Drug resistance
Glycosylation
Molecular Sequence Data
Molecular Structure
Peptides
Peptidoglycan - biosynthesis
Peptidoglycan - chemistry
Stereoisomerism
Uridine Diphosphate N-Acetylmuramic Acid - analogs & derivatives
Uridine Diphosphate N-Acetylmuramic Acid - chemical synthesis
Uridine Diphosphate N-Acetylmuramic Acid - chemistry
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Description
Summary:The problem of antibiotic resistance demands development of anti-infectives with novel modes of action. It is hoped that the present review demonstrates the transglycosylation reaction in peptidoglycan biosynthesis to be a promising target for new anti-infectives for a number of reasons.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr040634e