Magnetic resonance spectroscopy-guided transperineal prostate biopsy and brachytherapy for recurrent prostate cancer

Brachytherapy targeted to the peripheral zone with magnetic resonance imaging (MRI) guidance is a prostate cancer treatment option with potentially fewer complications than other treatments. Follow-up MRI when failure is suspected is, however, difficult because of radiation-induced changes. Furtherm...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 2005-12, Vol.66 (6), p.1319.e13-1319.e15
Main Authors: Szot Barnes, Agnieszka, Haker, Steven J., Mulkern, Robert V., So, Minna, D’Amico, Anthony V., Tempany, Clare M.
Format: Article
Language:English
Subjects:
Biopsy - methods
Brachytherapy - methods
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Middle Aged
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - radiotherapy
Prostatic Neoplasms - pathology
Prostatic Neoplasms - radiotherapy
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Description
Summary:Brachytherapy targeted to the peripheral zone with magnetic resonance imaging (MRI) guidance is a prostate cancer treatment option with potentially fewer complications than other treatments. Follow-up MRI when failure is suspected is, however, difficult because of radiation-induced changes. Furthermore, MR spectroscopy (MRS) is compromised by susceptibility artifacts from radioactive seeds in the peripheral zone. We report a case in which combined MRI/MRS was useful for the detection of prostate cancer in the transitional zone in patients previously treated with MR-guided brachytherapy. We propose that MRI/MRS can help detect recurrent prostate cancer, guide prostate biopsy, and help manage salvage treatment decisions.
ISSN:0090-4295
1527-9995
DOI:10.1016/j.urology.2005.06.105