Deficit in schizophrenia to recruit the striatum in implicit learning: A functional magnetic resonance imaging investigation

In schizophrenia, explicit learning deficits have been well established although it is less clear whether these patients have deficits in implicit learning (IL). IL is thought to depend on intact striatal functioning. This study examined the hypothesis that schizophrenia patients show deficient recr...

Full description

Saved in:
Bibliographic Details
Published in:Schizophrenia research 2006-10, Vol.87 (1), p.127-137
Main Authors: Reiss, Jeffrey P., Campbell, Darren W., Leslie, William D., Paulus, Martin P., Ryner, Lawrence N., Polimeni, Joseph O., Foot, Brendon J., Sareen, Jitender
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Caudate
Caudate Nucleus - blood supply
Caudate Nucleus - physiopathology
Cerebrovascular Circulation - physiology
Corpus Striatum - blood supply
Corpus Striatum - physiopathology
Female
fMRI
Frontal Lobe - blood supply
Frontal Lobe - metabolism
Gyrus Cinguli - blood supply
Humans
Implicit learning
Learning - physiology
Magnetic Resonance Imaging
Male
Medical sciences
Oxygen - blood
Procedural learning
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - physiopathology
Severity of Illness Index
Striatum
Temporal Lobe - blood supply
Temporal Lobe - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In schizophrenia, explicit learning deficits have been well established although it is less clear whether these patients have deficits in implicit learning (IL). IL is thought to depend on intact striatal functioning. This study examined the hypothesis that schizophrenia patients show deficient recruitment of striatal activation during an IL paradigm, relative to performance-matched healthy comparison subjects. Ten subjects with schizophrenia on atypical antipsychotic medication and 10 age, gender, education, and performance matched healthy comparison subjects underwent fMRI while performing an IL task. On the basis of whole-brain and striatal region-of-interest analyses, we found a relative lack of striatal activation in schizophrenia patients. This result is consistent with convergent evidence of striatal dysfunction in schizophrenia.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2006.04.027