Abnormal glycosylation of serum IgG in patients with IgA nephropathy

We postulated that IgA nephropathy (IgAN) involved alterations of serum IgG. The present study was undertaken to elucidate changes in serum IgG oligosaccharide structure analysis and to assess the diagnostic usefulness of this analysis in IgAN. The subjects were 28 children who were definitively dia...

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Bibliographic Details
Published in:Clinical and experimental nephrology 2006-09, Vol.10 (3), p.180-185
Main Authors: Homma, Hideki, Tozawa, Keiichi, Yasui, Takahiro, Itoh, Yasunori, Hayashi, Yutaro, Kohri, Kenjiro
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biopsy
Child
Child, Preschool
Chromatography, High Pressure Liquid - methods
Female
Glomerulonephritis, IGA - blood
Glomerulonephritis, IGA - diagnosis
Glycosylation
Humans
Immunoglobulin G - blood
Immunoglobulin G - chemistry
Kidney - pathology
Male
Middle Aged
Oligosaccharides - analysis
Oligosaccharides - chemistry
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Summary:We postulated that IgA nephropathy (IgAN) involved alterations of serum IgG. The present study was undertaken to elucidate changes in serum IgG oligosaccharide structure analysis and to assess the diagnostic usefulness of this analysis in IgAN. The subjects were 28 children who were definitively diagnosed as having IgAN on the basis of renal biopsy and who had not received treatment for this disease; 27 healthy children; 15 untreated adults definitely diagnosed as having IgAN; 5 patients with other nephropathies; and 61 healthy adults. Oligosaccharide analyses of IgG were performed by reverse-phase high-performance liquid chromatography (HPLC) developed by Takahashi and colleagues. In both the children and the adults, the peak area ratio of isomers with two different galactosyl-N-acetylglucosamine (Gal-GlcNAc) binding sites was significantly lower in the presence of IgAN than in the healthy subjects (P
ISSN:1342-1751
1437-7799
DOI:10.1007/s10157-006-0422-y