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Abnormal glycosylation of serum IgG in patients with IgA nephropathy
We postulated that IgA nephropathy (IgAN) involved alterations of serum IgG. The present study was undertaken to elucidate changes in serum IgG oligosaccharide structure analysis and to assess the diagnostic usefulness of this analysis in IgAN. The subjects were 28 children who were definitively dia...
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| Published in: | Clinical and experimental nephrology 2006-09, Vol.10 (3), p.180-185 |
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| cited_by | cdi_FETCH-LOGICAL-c349t-d392fa41e37bdf57eb7e9eb6525129af6784be52ae08592b33172592895318bd3 |
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| container_end_page | 185 |
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| container_start_page | 180 |
| container_title | Clinical and experimental nephrology |
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| creator | Homma, Hideki Tozawa, Keiichi Yasui, Takahiro Itoh, Yasunori Hayashi, Yutaro Kohri, Kenjiro |
| description | We postulated that IgA nephropathy (IgAN) involved alterations of serum IgG. The present study was undertaken to elucidate changes in serum IgG oligosaccharide structure analysis and to assess the diagnostic usefulness of this analysis in IgAN.
The subjects were 28 children who were definitively diagnosed as having IgAN on the basis of renal biopsy and who had not received treatment for this disease; 27 healthy children; 15 untreated adults definitely diagnosed as having IgAN; 5 patients with other nephropathies; and 61 healthy adults. Oligosaccharide analyses of IgG were performed by reverse-phase high-performance liquid chromatography (HPLC) developed by Takahashi and colleagues.
In both the children and the adults, the peak area ratio of isomers with two different galactosyl-N-acetylglucosamine (Gal-GlcNAc) binding sites was significantly lower in the presence of IgAN than in the healthy subjects (P |
| doi_str_mv | 10.1007/s10157-006-0422-y |
| format | article |
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The subjects were 28 children who were definitively diagnosed as having IgAN on the basis of renal biopsy and who had not received treatment for this disease; 27 healthy children; 15 untreated adults definitely diagnosed as having IgAN; 5 patients with other nephropathies; and 61 healthy adults. Oligosaccharide analyses of IgG were performed by reverse-phase high-performance liquid chromatography (HPLC) developed by Takahashi and colleagues.
In both the children and the adults, the peak area ratio of isomers with two different galactosyl-N-acetylglucosamine (Gal-GlcNAc) binding sites was significantly lower in the presence of IgAN than in the healthy subjects (P<0.05 in children and P<0.001 in adults). The ratio of Gal-free oligosaccharides to Gal-positive oligosaccharides did not differ according to the presence or absence of IgAN in children or in adults.
The analysis of the oligosaccharide structure of serum IgG seems to be useful in diagnosing IgAN.</description><identifier>ISSN: 1342-1751</identifier><identifier>EISSN: 1437-7799</identifier><identifier>DOI: 10.1007/s10157-006-0422-y</identifier><identifier>PMID: 17009075</identifier><identifier>CODEN: CENPFV</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>Adolescent ; Adult ; Biopsy ; Child ; Child, Preschool ; Chromatography, High Pressure Liquid - methods ; Female ; Glomerulonephritis, IGA - blood ; Glomerulonephritis, IGA - diagnosis ; Glycosylation ; Humans ; Immunoglobulin G - blood ; Immunoglobulin G - chemistry ; Kidney - pathology ; Male ; Middle Aged ; Oligosaccharides - analysis ; Oligosaccharides - chemistry</subject><ispartof>Clinical and experimental nephrology, 2006-09, Vol.10 (3), p.180-185</ispartof><rights>Japanese Society of Nephrology 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-d392fa41e37bdf57eb7e9eb6525129af6784be52ae08592b33172592895318bd3</citedby><cites>FETCH-LOGICAL-c349t-d392fa41e37bdf57eb7e9eb6525129af6784be52ae08592b33172592895318bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17009075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Homma, Hideki</creatorcontrib><creatorcontrib>Tozawa, Keiichi</creatorcontrib><creatorcontrib>Yasui, Takahiro</creatorcontrib><creatorcontrib>Itoh, Yasunori</creatorcontrib><creatorcontrib>Hayashi, Yutaro</creatorcontrib><creatorcontrib>Kohri, Kenjiro</creatorcontrib><title>Abnormal glycosylation of serum IgG in patients with IgA nephropathy</title><title>Clinical and experimental nephrology</title><addtitle>Clin Exp Nephrol</addtitle><description>We postulated that IgA nephropathy (IgAN) involved alterations of serum IgG. The present study was undertaken to elucidate changes in serum IgG oligosaccharide structure analysis and to assess the diagnostic usefulness of this analysis in IgAN.
The subjects were 28 children who were definitively diagnosed as having IgAN on the basis of renal biopsy and who had not received treatment for this disease; 27 healthy children; 15 untreated adults definitely diagnosed as having IgAN; 5 patients with other nephropathies; and 61 healthy adults. Oligosaccharide analyses of IgG were performed by reverse-phase high-performance liquid chromatography (HPLC) developed by Takahashi and colleagues.
In both the children and the adults, the peak area ratio of isomers with two different galactosyl-N-acetylglucosamine (Gal-GlcNAc) binding sites was significantly lower in the presence of IgAN than in the healthy subjects (P<0.05 in children and P<0.001 in adults). The ratio of Gal-free oligosaccharides to Gal-positive oligosaccharides did not differ according to the presence or absence of IgAN in children or in adults.
The analysis of the oligosaccharide structure of serum IgG seems to be useful in diagnosing IgAN.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biopsy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Female</subject><subject>Glomerulonephritis, IGA - blood</subject><subject>Glomerulonephritis, IGA - diagnosis</subject><subject>Glycosylation</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - chemistry</subject><subject>Kidney - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oligosaccharides - analysis</subject><subject>Oligosaccharides - chemistry</subject><issn>1342-1751</issn><issn>1437-7799</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNpdkMFLwzAYxYMoTqd_gBcpHrxFvyRN0xzH1DkYeNFzSNp062ibmrRI_3szNhA8fY_He4-PH0J3BJ4IgHgOBAgXGCDDkFKKpzN0RVImsBBSnkfNUoqJ4GSGrkPYA0AuubxEMyIAJAh-hV4WpnO-1U2ybabChanRQ-26xFVJsH5sk_V2ldRd0kfbdkNIfuphF81F0tl-5130d9MNuqh0E-zt6c7R19vr5_Idbz5W6-VigwuWygGXTNJKp8QyYcqKC2uEldZknHJCpa4ykafGcqot5FxSwxgRNIr4NCO5KdkcPR53e---RxsG1dahsE2jO-vGoLJcQpZJGYMP_4J7N_ou_qYoyQnjFCCGyDFUeBeCt5Xqfd1qPykC6sBXHfmqyFcd-Kopdu5Pw6NpbfnXOAFlv8mRdLs</recordid><startdate>200609</startdate><enddate>200609</enddate><creator>Homma, Hideki</creator><creator>Tozawa, Keiichi</creator><creator>Yasui, Takahiro</creator><creator>Itoh, Yasunori</creator><creator>Hayashi, Yutaro</creator><creator>Kohri, Kenjiro</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200609</creationdate><title>Abnormal glycosylation of serum IgG in patients with IgA nephropathy</title><author>Homma, Hideki ; Tozawa, Keiichi ; Yasui, Takahiro ; Itoh, Yasunori ; Hayashi, Yutaro ; Kohri, Kenjiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-d392fa41e37bdf57eb7e9eb6525129af6784be52ae08592b33172592895318bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biopsy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Female</topic><topic>Glomerulonephritis, IGA - blood</topic><topic>Glomerulonephritis, IGA - diagnosis</topic><topic>Glycosylation</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - chemistry</topic><topic>Kidney - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oligosaccharides - analysis</topic><topic>Oligosaccharides - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Homma, Hideki</creatorcontrib><creatorcontrib>Tozawa, Keiichi</creatorcontrib><creatorcontrib>Yasui, Takahiro</creatorcontrib><creatorcontrib>Itoh, Yasunori</creatorcontrib><creatorcontrib>Hayashi, Yutaro</creatorcontrib><creatorcontrib>Kohri, Kenjiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health Medical collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Homma, Hideki</au><au>Tozawa, Keiichi</au><au>Yasui, Takahiro</au><au>Itoh, Yasunori</au><au>Hayashi, Yutaro</au><au>Kohri, Kenjiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal glycosylation of serum IgG in patients with IgA nephropathy</atitle><jtitle>Clinical and experimental nephrology</jtitle><addtitle>Clin Exp Nephrol</addtitle><date>2006-09</date><risdate>2006</risdate><volume>10</volume><issue>3</issue><spage>180</spage><epage>185</epage><pages>180-185</pages><issn>1342-1751</issn><eissn>1437-7799</eissn><coden>CENPFV</coden><abstract>We postulated that IgA nephropathy (IgAN) involved alterations of serum IgG. The present study was undertaken to elucidate changes in serum IgG oligosaccharide structure analysis and to assess the diagnostic usefulness of this analysis in IgAN.
The subjects were 28 children who were definitively diagnosed as having IgAN on the basis of renal biopsy and who had not received treatment for this disease; 27 healthy children; 15 untreated adults definitely diagnosed as having IgAN; 5 patients with other nephropathies; and 61 healthy adults. Oligosaccharide analyses of IgG were performed by reverse-phase high-performance liquid chromatography (HPLC) developed by Takahashi and colleagues.
In both the children and the adults, the peak area ratio of isomers with two different galactosyl-N-acetylglucosamine (Gal-GlcNAc) binding sites was significantly lower in the presence of IgAN than in the healthy subjects (P<0.05 in children and P<0.001 in adults). The ratio of Gal-free oligosaccharides to Gal-positive oligosaccharides did not differ according to the presence or absence of IgAN in children or in adults.
The analysis of the oligosaccharide structure of serum IgG seems to be useful in diagnosing IgAN.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>17009075</pmid><doi>10.1007/s10157-006-0422-y</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adult Biopsy Child Child, Preschool Chromatography, High Pressure Liquid - methods Female Glomerulonephritis, IGA - blood Glomerulonephritis, IGA - diagnosis Glycosylation Humans Immunoglobulin G - blood Immunoglobulin G - chemistry Kidney - pathology Male Middle Aged Oligosaccharides - analysis Oligosaccharides - chemistry |
| title | Abnormal glycosylation of serum IgG in patients with IgA nephropathy |
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