Global tests of haemostasis in critically ill patients with severe sepsis syndrome compared to controls

Summary Haemostatic changes in septic patients are complex, with both procoagulant and anticoagulant changes. Thirty‐eight patients with severe sepsis and 32 controls were investigated by coagulation screens, individual factor assays, calibrated automated thrombography (CAT), whole blood low‐dose‐ti...

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Bibliographic Details
Published in:British journal of haematology 2006-10, Vol.135 (2), p.220-227
Main Authors: Collins, Peter W., Macchiavello, Luis I., Lewis, Sarah J., Macartney, Nichola J., Saayman, Anton G., Luddington, Roger, Baglin, Trevor, Findlay, George P.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Blood Coagulation Factors - metabolism
Blood Coagulation Tests - methods
C-Reactive Protein - metabolism
global haemostasis
Hematologic and hematopoietic diseases
Hemostasis
Humans
Medical sciences
Middle Aged
Protein C - metabolism
sepsis
Systemic Inflammatory Response Syndrome - blood
Thrombelastography - methods
Thrombin - biosynthesis
thrombin generation
thromboelastography
Thromboplastin - metabolism
thrombosis
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Summary:Summary Haemostatic changes in septic patients are complex, with both procoagulant and anticoagulant changes. Thirty‐eight patients with severe sepsis and 32 controls were investigated by coagulation screens, individual factor assays, calibrated automated thrombography (CAT), whole blood low‐dose‐tissue factor activated (LD‐TFA) Rotem and LD‐TFA waveform analysis. Thirty‐six of 38 patients had an abnormal coagulation screen. The mean levels of factors II, V (P 
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2006.06281.x