Thioredoxin-binding protein-2 (TBP-2): Its potential roles in the aging process

Thioredoxin (TRX) binding protein‐2 (TBP‐2), a negative regulator of TRX, is involved in intracellular redox regulation and cellular growth. The expression of TBP‐2 is frequently lost in tumor cell lines and tissues, whereas the ectopic expression of TBP‐2 suppresses cellular proliferation along wit...

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Bibliographic Details
Published in:BioFactors (Oxford) 2006, Vol.27 (1-4), p.47-51
Main Authors: Yoshida, Toru, Kondo, Norihiko, Oka, Shin-Ichi, Ahsan, Md Kaimul, Hara, Tomijiro, Masutani, Hiroshi, Nakamura, Hajime, Ab, Junji Yodoi
Format: Article
Language:English
Subjects:
aging
Animals
Apoptosis - physiology
Carrier Proteins - physiology
Cell Cycle - physiology
Cellular Senescence - physiology
energy metabolism
Energy Metabolism - physiology
Humans
lipid
Models, Biological
Oxidation-Reduction
redox
Thioredoxin
Thioredoxins
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Summary:Thioredoxin (TRX) binding protein‐2 (TBP‐2), a negative regulator of TRX, is involved in intracellular redox regulation and cellular growth. The expression of TBP‐2 is frequently lost in tumor cell lines and tissues, whereas the ectopic expression of TBP‐2 suppresses cellular proliferation along with cell cycle arrest at the G1 phase. TBP‐2 was also reported to be a cellular senescence‐associated gene. Besides the retardation of cellular growth, the reduction of white adipose, and alteration of the energy pathway are involved in several features of the aging process. We have generated TBP‐2 genetically modified mice and found that TBP‐2 is closely linked to lipid metabolism. Indeed, TBP‐2 has been suggesting to be related to familial combined hyperlipidemia analyzed by a spontaneous mutant mouse strain. As lipid metabolism is one of the most primitive sources of energy production, we discussed the possible roles of TBP‐2 in the regulation of energy utilization connected to the aging process.
ISSN:0951-6433
1872-8081
DOI:10.1002/biof.5520270105