Urinary neopterin in patients with advanced colorectal carcinoma

In previous studies, mostly in patients with early stage colorectal carcinoma, neopterin, an indicator of systemic immune activation, has been associated with poor prognosis. The aim of the present study was to evaluate urinary neopterin in patients with advanced or metastatic colorectal carcinoma t...

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Bibliographic Details
Published in:The International journal of biological markers 2006-07, Vol.21 (3), p.190-198
Main Authors: MELICHAR, B, SOLICHOVA, D, MELICHAROVA, K, MALIROVA, E, CERMANOVA, M, ZADAK, Z
Format: Article
Language:English
Subjects:
Adult
Aged
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Biomarkers, Tumor - urine
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - secondary
Colorectal Neoplasms - urine
Female
Fundamental and applied biological sciences. Psychology
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Neopterin - urine
Prognosis
Retrospective Studies
Survival Analysis
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Summary:In previous studies, mostly in patients with early stage colorectal carcinoma, neopterin, an indicator of systemic immune activation, has been associated with poor prognosis. The aim of the present study was to evaluate urinary neopterin in patients with advanced or metastatic colorectal carcinoma treated with chemotherapy. A retrospective analysis was performed of urinary neopterin, determined by high-performance liquid chromatography, in 88 patients with advanced or metastatic colorectal carcinoma. Peripheral blood cell count and serum carcinoembryonic antigen (CEA) were determined in 72 patients before the start of chemotherapy. Urinary neopterin in colorectal carcinoma patients was significantly increased compared to controls, but lower than in patients with inflammatory bowel disease. Neopterin correlated significantly with serum CEA, age, peripheral blood leukocyte and platelet counts. The median survival of colorectal carcinoma patients with urinary neopterin below 214 micromol/mol creatinine was significantly longer compared to that of patients with higher neopterin concentrations (median 18 vs 5 months, log-rank test p=0.003). CEA and hemoglobin were also associated with survival in univariate analysis, but in multivariate analysis only urinary neopterin and serum CEA were independent predictors of survival. High urinary neopterin during follow-up was also predictive of poor prognosis.
ISSN:0393-6155
1724-6008
DOI:10.1177/172460080602100309