"Melanoma inhibitory activity" (MIA): a promising serological tumour marker in metastatic uveal melanoma

• Published in: Graefe's archive for clinical and experimental ophthalmology 2005-11, Vol.243 (11), p.1161-1166
• Main Authors: Reiniger, I W, Schaller, U C, Haritoglou, C, Hein, R, Bosserhoff, A K, Kampik, A, Mueller, A J
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor - blood; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix Proteins; Female; Humans; Liver Neoplasms - blood; Liver Neoplasms - secondary; Male; Melanoma - blood; Melanoma - diagnostic imaging; Melanoma - secondary; Middle Aged; Neoplasm Proteins - blood; Ophthalmology; Prospective Studies; Ultrasonography; Uveal Neoplasms - blood; Uveal Neoplasms - diagnostic imaging; Uveal Neoplasms - pathology
• ISSN: 0721-832X; 1435-702X
• DOI: 10.1007/s00417-005-1171-4

To assess the role of "melanoma inhibitory activity" (MIA) as a potential serum marker for screening and detection of metastatic uveal melanoma. Prospective, clinical study. Serum samples of 305 patients with uveal melanoma were collected. Serum samples were analysed by a one-step enzyme-linked immunosorbent assay (ELISA) to quantify the MIA serum levels. All patients underwent a standardized echography of the globe to evaluate maximum tumour height and were checked for systemic metastasis of the tumour by liver enzyme tests and ultrasonography of the liver. Twenty patients (6.6%) had proven metastatic disease; eight of them developed it during follow-up. The mean serum concentration of MIA in the 285 patients without metastasis was 6.72 ng/ml, whereas the mean serum concentration of MIA in the 20 patients with metastasis was 13.03 ng/ml (P