Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans

By combining all the data available from the Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) project, we have been able to identify 17 microsatellite markers showing consistent evidence for apparent association. As might be expected five of these markers map within the Major Histocompati...

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Bibliographic Details
Published in:Journal of neuroimmunology 2006-10, Vol.179 (1), p.108-116
Main Authors: Santos, Monica, Maciel, P., The GAMES Collaborative Group
Format: Article
Language:English
Subjects:
Calcium-Binding Proteins - genetics
Europe
Europe - epidemiology
Female
Genetic Predisposition to Disease
Genetic Testing
Genome screen
Genotype
Humans
Intercellular Signaling Peptides and Proteins
Intercellular Signaling Peptides and Proteins - genetics
JAG1
Jagged-1 Protein
Linkage Disequilibrium
Linkage Disequilibrium - genetics
Male
Membrane Proteins
Membrane Proteins - genetics
Meta-analysis
Microsatellite Repeats
Multiple Sclerosis
Multiple Sclerosis - epidemiology
Multiple Sclerosis - genetics
POU2AF1
Serrate-Jagged Proteins
Trans-Activators - genetics
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Summary:By combining all the data available from the Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) project, we have been able to identify 17 microsatellite markers showing consistent evidence for apparent association. As might be expected five of these markers map within the Major Histocompatibility Complex (MHC) and are in LD with HLA-DRB1. Individual genotyping of the 12 non-MHC markers confirmed association for three of them — D11S1986, D19S552 and D20S894. Association mapping across the candidate genes implicated by these markers in 937 UK trio families revealed modestly associated haplotypes in JAG1 ( p = 0.019) on chromosome 20p12.2 and POU2AF1 ( p = 0.003) on chromosome 11q23.1.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2006.06.003