Genome-Wide Linkage Analysis to Identify Chromosomal Regions Affecting Phenotypic Traits in the Chicken. I. Growth and Average Daily Gain

A genome scan was used to detect chromosomal regions and QTL that control quantitative traits of economic importance in chickens. Two unique F2 crosses generated from a commercial broiler male line and 2 genetically distinct inbred lines (Leghorn and Fayoumi) were used to identify QTL affecting BW a...

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Bibliographic Details
Published in:Poultry science 2006-10, Vol.85 (10), p.1700-1711
Main Authors: Zhou, H, Deeb, N, Evock-Clover, C.M, Ashwell, C.M, Lamont, S.J
Format: Article
Language:English
Subjects:
animal growth
Animals
body weight
broiler breeders
chickens
Chickens - genetics
Chickens - growth & development
chromosome mapping
Chromosome Mapping - veterinary
Crosses, Genetic
crossing
Genetic Linkage
Genome
genotype
growth traits
inbred lines
laying hens
linkage (genetics)
microsatellite repeats
Phenotype
quantitative trait loci
Quantitative Trait Loci - genetics
Weight Gain - genetics
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Summary:A genome scan was used to detect chromosomal regions and QTL that control quantitative traits of economic importance in chickens. Two unique F2 crosses generated from a commercial broiler male line and 2 genetically distinct inbred lines (Leghorn and Fayoumi) were used to identify QTL affecting BW and daily average gain traits in chickens. Body weight at 2, 4, 6, and 8 wk was measured in the 2 F2 crosses. Birds were genotyped for 269 microsatellite markers across the entire genome. Linkage distance among microsatellite markers was estimated by the CRIMAP program. The program QTL Express was used for QTL detection. Significance levels were obtained using the permutation test. For the 8 traits, a total of 18 and 13 significant QTL were detected at a 1% chromosome-wise significance level, of which 17 and 10 were significant at the 5% genome-wise level for the broiler-Leghorn cross and broiler-Fayoumi cross, respectively. Highly correlated growth traits showed similar QTL profiles within each cross but different QTL profiles between the 2 crosses. Most QTL for growth traits in the current study were detected in Gga 1, 2, 4, 7, and 14 for the broiler-Leghorn cross and Gga 1, 2, 4, 5, 8, and 13 for the broiler-Fayoumi cross. Potential candidate genes within the QTL region for growth traits at 1% chromosome-wise significance level were discussed. The results in the current study lay the foundations for fine mapping these traits in the advanced intercross lines and provide a start point for identification causative genes responsible for growth traits in chickens.
ISSN:0032-5791
1525-3171
DOI:10.1093/ps/85.10.1700