A Paranasal Tumor Associated With Tumor-Induced Osteomalacia

Background: Tumor‐induced osteomalacia (TIO) is an extremely rare paraneoplastic syndrome associated with mesenchymal tumors in the craniofacial region. Methods: We treated a 24‐year‐old Japanese woman with paranasal sinus tumor and a low serum phosphate level who presented with nasal obstruction an...

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Bibliographic Details
Published in:The Laryngoscope 2006-10, Vol.116 (10), p.1930-1933
Main Authors: Inokuchi, Go, Tanimoto, Hitoshi, Ishida, Haruhiko, Sugimoto, Toshitsugu, Yamauchi, Mika, Miyauchi, Akimitsu, Nibu, Ken-ichi
Format: Article
Language:English
Subjects:
Adult
Alkaline Phosphatase - blood
Biological and medical sciences
Biomarkers, Tumor - blood
Bone Density - physiology
Diseases of the osteoarticular system
Female
fibroblast growth factor 23
Fibroblast Growth Factors - blood
Follow-Up Studies
Fractures, Bone - etiology
Humans
Medical sciences
Mesenchymoma - complications
Mesenchymoma - surgery
Nasal Obstruction - etiology
Osteomalacia - etiology
Osteoporosis. Osteomalacia. Paget disease
Otorhinolaryngology. Stomatology
Paranasal Sinus Neoplasms - complications
Paranasal Sinus Neoplasms - surgery
paranasal tumor
Paraneoplastic Syndromes - etiology
Phosphates - blood
Tumor-induced osteomalacia
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Summary:Background: Tumor‐induced osteomalacia (TIO) is an extremely rare paraneoplastic syndrome associated with mesenchymal tumors in the craniofacial region. Methods: We treated a 24‐year‐old Japanese woman with paranasal sinus tumor and a low serum phosphate level who presented with nasal obstruction and systemic bone fractures. Serum fibroblast growth factor 23 (FGF‐23) was measured before and after surgery. Results: After surgery, her symptoms were resolved and the serum phosphate and FGF‐23 levels became normalized. Conclusion: FGF‐23 is thought to be a useful diagnostic marker in patients with craniofacial tumors associated with multiple systemic fractures.
ISSN:0023-852X
1531-4995
DOI:10.1097/01.mlg.0000231295.67060.89