Spontaneous skin necrosis from acquired protein S deficiency in a renal transplant recipient

Spontaneous skin necrosis revealed acquired protein S deficiency due to isotype G autoantibodies. This 31-year-old male renal transplant recipient, receiving immunosuppressive treatment, was hospitalized for necrotic purpural lesions. We were not able to detect any triggering factor. Sustained antic...

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Bibliographic Details
Published in:La Presse médicale (1983) 2005-12, Vol.34 (22 Pt 1), p.1710-1712
Main Authors: Laurat, E, Frouget, T, Joyeux, V, Arvieux, C, Pommereuil, M, Chevrant-Breton, J
Format: Article
Language:fre
Subjects:
Adult
Anticoagulants - therapeutic use
Autoantibodies - blood
Heparin - therapeutic use
Humans
Immunoglobulin G - immunology
Kidney Transplantation - immunology
Male
Necrosis
Protein S Deficiency - diagnosis
Protein S Deficiency - immunology
Skin - pathology
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Summary:Spontaneous skin necrosis revealed acquired protein S deficiency due to isotype G autoantibodies. This 31-year-old male renal transplant recipient, receiving immunosuppressive treatment, was hospitalized for necrotic purpural lesions. We were not able to detect any triggering factor. Sustained anticoagulant therapy remained essential to prevent new skin lesions and perhaps more thrombotic events. This condition is rare in adulthood, but is well described in children's purpura fulminans, especially the post-varicella form. Its mechanism remains unclear.
ISSN:0755-4982
DOI:10.1016/S0755-4982(05)84255-1