Isolated IgG3 deficiency in children: to treat or not to treat? Case presentation and review of the literature

Immunoglobulin G3 (IgG3) subclass deficiency has received rather little attention thus far. In this report, the clinical and immunologic characteristics of six children with isolated IgG3 deficiency are discussed. The currently available literature on IgG3 deficiency is reviewed with specific emphas...

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Bibliographic Details
Published in:Pediatric allergy and immunology 2006-11, Vol.17 (7), p.544-550
Main Authors: Meyts, Isabelle, Bossuyt, X, Proesmans, M, De, Boeck
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - immunology
antibody deficiency
Biological and medical sciences
Child
Child, Preschool
Female
Humans
IgG Deficiency - blood
IgG Deficiency - drug therapy
IgG Deficiency - immunology
IgG3
Immunoglobulins, Intravenous - therapeutic use
Immunopathology
Lymphocyte Count
Male
Mannose-Binding Lectin - genetics
Medical sciences
Pneumococcal Vaccines - administration & dosage
Polymorphism, Genetic
Polysaccharides, Bacterial - immunology
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Description
Summary:Immunoglobulin G3 (IgG3) subclass deficiency has received rather little attention thus far. In this report, the clinical and immunologic characteristics of six children with isolated IgG3 deficiency are discussed. The currently available literature on IgG3 deficiency is reviewed with specific emphasis on the peculiarities of the IgG3 subclass, the clinical relevance of IgG3 deficiency as well as the therapeutic options.
ISSN:0905-6157
1399-3038
DOI:10.1111/j.1399-3038.2006.00454.x