A new paradigm for membrane-organizing and -shaping scaffolds

The clathrin, COPI and COPII scaffolds are paradigm vesicle coats in membrane trafficking. Recent advances in our understanding of the caveolar coat have generated a new paradigm. It represents those membrane coats, where a considerable part of the protein component is lipid modified, and integrated...

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Bibliographic Details
Published in:FEBS letters 2006-10, Vol.580 (23), p.5559-5564
Main Authors: Bauer, Manuel, Pelkmans, Lucas
Format: Article
Language:English
Subjects:
Animals
Caveolin
Caveolins - metabolism
Cell Membrane - chemistry
Cell Membrane - metabolism
Disease
Flotillin
Membrane Proteins - metabolism
Nerve Tissue Proteins - metabolism
Reticulon
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Summary:The clathrin, COPI and COPII scaffolds are paradigm vesicle coats in membrane trafficking. Recent advances in our understanding of the caveolar coat have generated a new paradigm. It represents those membrane coats, where a considerable part of the protein component is lipid modified, and integrated into the cytosolic leaflet of the vesicle membrane by a hairpin-like hydrophobic structure. Such coat proteins are permanently associated with membranes, and form oligomers early after synthesis. These oligomers assemble into a coat that has high affinity for particular lipids, creating lipid microdomains within the membrane. The combined protein–lipid structure should be considered as the scaffold that entraps ligands, either through affinity with the protein or with the lipid component, and that has the ability to shape membranes. Besides scaffolds assembled by caveolins, scaffolds assembled by reticulons and PHB domain-containing proteins such as the reggie/flotillin proteins fit this paradigm.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2006.08.077