Renal Denervation Does Not Abolish Sustained Baroreflex-Mediated Reductions in Arterial Pressure

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2007-02, Vol.49 (2), p.373-379
• Main Authors: Lohmeier, Thomas E, Hildebrandt, Drew A, Dwyer, Terry M, Barrett, Austin M, Irwin, Eric D, Rossing, Martin A, Kieval, Robert S
• Format: Article
• Language: English
• Subjects: Animals; Arterial hypertension. Arterial hypotension; Baroreflex - physiology; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - physiology; Blood Proteins - metabolism; Cardiology. Vascular system; Carotid Arteries - physiology; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Denervation; Dogs; Electric Stimulation; Fundamental and applied biological sciences. Psychology; Heart Rate - physiology; Hematocrit; Kidney - innervation; Kidney - metabolism; Male; Medical sciences; Norepinephrine - blood; Norepinephrine - metabolism; Osmolar Concentration; Potassium - blood; Potassium - urine; Renin - blood; Sodium - blood; Sodium - urine; Sympathetic Nervous System - physiology; Time Factors; Vertebrates: urinary system
• ISSN: 0194-911X; 1524-4563; 1524-4563
• DOI: 10.1161/01.HYP.0000253507.56499.bb

Recent studies indicate that suppression of renal sympathetic nerve activity and attendant increments in renal excretory function are sustained baroreflex-mediated responses in hypertensive animals. Given the central role of the kidneys in long-term regulation of arterial pressure, we hypothesized that the chronic blood pressure–lowering effects of the baroreflex are critically dependent on intact renal innervation. This hypothesis was tested in 6 dogs by bilaterally activating the carotid baroreflex electrically for 7 days before and after bilateral renal denervation. Before renal denervation, control values for mean arterial pressure and plasma norepinephrine concentration were 95±2 mm Hg and 96±12 pg/mL, respectively. During day 1 of baroreflex activation, mean arterial pressure decreased 13±1 mm Hg, and there was modest sodium retention. Daily sodium balance was subsequently restored, but reductions in mean arterial pressure were sustained throughout the 7 days of baroreflex activation. Activation of the baroreflex was associated with sustained decreases in plasma norepinephrine concentration (≈50%) and plasma renin activity (30% to 40%). All of the values returned to control levels during a 7-day recovery period. Two weeks after renal denervation, control values for mean arterial pressure, plasma norepinephrine concentration, plasma renin activity, and sodium excretion were comparable to those measured when the renal nerves were intact. Moreover, after renal denervation, all of the responses to activation of the baroreflex were similar to those observed before renal denervation. These findings demonstrate that the presence of the renal nerves is not an obligate requirement for achieving long-term reductions in arterial pressure during prolonged activation of the baroreflex.