The Effect of Steroids on the Clinical Course and Outcome of Neonates with Meconium Aspiration Syndrome

Meconium Aspiration Syndrome (MAS) is an important cause of neonatal morbidity and mortality. The present study was undertaken to evaluate the role of steroids in the management of MAS. This was a double blinded randomized controlled trial and a prospective Interventional Study over one-year period...

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Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 2007-02, Vol.53 (1), p.8-12
Main Authors: Tripathi, Sandeep, Saili, Arvind
Format: Article
Language:English
Subjects:
Analysis of Variance
Biological and medical sciences
Budesonide - administration & dosage
Budesonide - therapeutic use
Double-Blind Method
Female
General aspects
Glucocorticoids - administration & dosage
Glucocorticoids - therapeutic use
Humans
India
Infant, Newborn
Injections, Intravenous
Male
Meconium Aspiration Syndrome - drug therapy
Medical sciences
Methylprednisolone - administration & dosage
Methylprednisolone - therapeutic use
Nebulizers and Vaporizers
Pneumology
Prospective Studies
Respiratory system : syndromes and miscellaneous diseases
Statistics, Nonparametric
Treatment Outcome
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Summary:Meconium Aspiration Syndrome (MAS) is an important cause of neonatal morbidity and mortality. The present study was undertaken to evaluate the role of steroids in the management of MAS. This was a double blinded randomized controlled trial and a prospective Interventional Study over one-year period in the neonatal unit of the Lady Hardinge Medical College and associated Kalawati Saran Children's hospital. Fifty-one babies of MAS which were randomly distributed into three groups, Control, systemic and nebulized steroids. Methyl prednisolone was given i.v. in dose of 0.5 mg/kg/day in two divided doses. Budecort was given by nebulization in dose of 50 microgram 12 hourly. Infants were assessed in terms of duration of stay, oxygen dependence, X-ray clearances and also assessed for short term adverse effects. There was a statistically significant difference in the duration of stay, duration of oxygen dependence and radiological clearance. The use of steroids was not associated with an increased incidence of sepsis. The conclusion is that steroids alter the course of Meconium Aspiration Syndrome and favorably affect the outcome.
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/fml018